Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs
Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs
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DOI：
10.1111/j.1467-2995.2011.00700.x
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发表时间：
2012-03-01
影响因子：
1.7
通讯作者：
Hartman, Marthinus
中科院分区：
文献类型：
--
作者：
Suarez, Martin A.;Dzikiti, Brighton T.;Hartman, Marthinus
目的比较阿法沙酮和丙泊酚用于犬卵巢切除术全凭静脉麻醉（TIVA）的麻醉效果和心肺功能。研究设计：前瞻性非盲随机临床研究。动物14只健康的雌性杂种母犬，年龄0.55岁，体重1642 kg。方法预先给予乙酰丙嗪0.01 mg kg-1和吗啡0.4 mg kg-1。用丙泊酚或阿法沙酮诱导和维持麻醉，以实现气管插管，然后输注相同的药物。犬通过循环回路自主呼吸，并补充氧气。连续测量心脏参数（呼吸和心率、潮气末二氧化碳、潮气量和有创血压），并在与手术相关的时间间隔记录。分析动脉血样本的血气值。确定了诱导和恢复的质量以及恢复时间。使用MannWhitney U-检验检验非参数数据的组间显著差异，并通过方差分析重复测量数据（正态分布）的组间和组内显著差异。结果异丙酚和阿法沙龙注射液及后续输注均能顺利、迅速地诱导麻醉，维持麻醉效果满意。诱导剂量（平均值+/- SD）分别为5.8 +/- 0.30和1.9 +/- 0.07 mg kg-1，对于CRI，丙泊酚和阿法沙酮分别为0.37 +/- 0.09和0.11 +/- 0.01 mg kg-1/min。丙泊酚和阿法沙龙的中位（IQR）恢复时间分别为胸骨45（3369）和60（4661），站立74（6976）和90（85107）。恢复质量良好。两组之间的心脏效应没有差异。两组均发生肺通气不足。结论和临床相关性：术前给予乙酰丙嗪和吗啡后，丙泊酚和阿法沙龙均可产生良好的麻醉效果，足以用于卵巢子宫切除术。发生通气不足，表明在使用任一麻醉剂的延长输注期间需要呼吸支持。
Objective To compare the anaesthetic and cardiopulmonary effects of alfaxalone with propofol when used for total intravenous anaesthesia (TIVA) during ovariohysterectomy in dogs. Study design A prospective non-blinded randomized clinical study. Animals Fourteen healthy female crossbred bitches, aged 0.55 years and weight 1642 kg. Methods Dogs were premedicated with acepromazine 0.01 mg kg-1 and morphine 0.4 mg kg-1. Anaesthesia was induced and maintained with either propofol or alfaxalone to effect for tracheal intubation followed by an infusion of the same agent. Dogs breathed spontaneously via a circle circuit, with oxygen supplementation. Cardiopulmonary parameters (respiratory and heart rates, end-tidal carbon dioxide, tidal volume, and invasive blood pressures) were measured continuously and recorded at intervals related to the surgical procedure. Arterial blood samples were analysed for blood gas values. Quality of induction and recovery, and recovery times were determined. Non-parametric data were tested for significant differences between groups using the MannWhitney U-test and repeatedly measured data (normally distributed) for significant differences between and within groups by anova. Results Both propofol and alphaxalone injection and subsequent infusions resulted in smooth, rapid induction and satisfactory maintenance of anaesthesia. Doses for induction (mean +/- SD) were 5.8 +/- 0.30 and 1.9 +/- 0.07 mg kg-1 and for the CRIs, 0.37 +/- 0.09 and 0.11 +/- 0.01 mg kg-1 per minute for propofol and alfaxalone respectively. Median (IQR) recovery times were to sternal 45 (3369) and 60 (4661) and to standing 74 (6976) and 90 (85107) for propofol and alphaxalone respectively. Recovery quality was good. Cardiopulmonary effects did not differ between groups. Hypoventilation occurred in both groups. Conclusions and clinical relevance Following premedication with acepromazine and morphine, both propofol and alphaxalone produce good quality anaesthesia adequate for ovariohysterectomy. Hypoventilation occurs suggesting a need for ventilatory support during prolonged infusion periods with either anaesthetic agent.