Altered Glucocorticoid Regulation of the Immune Response in the Chronic Fatigue Syndrome
Altered Glucocorticoid Regulation of the Immune Response in the Chronic Fatigue Syndrome
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DOI：
10.1111/j.1749-6632.2000.tb05453.x
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发表时间：
2000-01
影响因子：
5.2
通讯作者：
J. Visser;E. R. Kloet;L. Nagelkerken
中科院分区：
文献类型：
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作者：
J. Visser;E. R. Kloet;L. Nagelkerken
摘要：越来越多的人认识到，糖皮质激素（GCS）在免疫调节中具有微妙的调节作用，而不是具有普遍的免疫抑制作用。GC抑制Th 1细胞和细胞免疫，但可能有利于Th 2应答和体液免疫。慢性疲劳综合征（CFS）似乎与HPA轴紊乱有关。此外，CFS患者表现出几种免疫学变化，提示细胞免疫力下降。本文假设CFS患者中Th 1/Th 2平衡降低可能是GC对IL-10/IL-12调节回路的选择性作用的结果。
Abstract: It is increasingly recognized that glucocortiocoids (GCS) can have subtle modulatory effects in immunoregulation rather than having generalized immunosuppressive effects. GCs suppress Th1 cells and cellular immunity, but may favor Th2 responses and humoral immunity. The chronic fatigue syndrome (CFS) appears to be associated with a disturbed HPA‐axis. Moreover, CFS patients show several immunological changes suggestive of decreased cellular immunity. It is postulated herein that in CFS patients a decreased Th1/Th2 balance may be the result of selective effects of GC on the IL‐10/IL‐12 regulatory circuit.