Regional specificity of RAR gamma isoforms in Xenopus development.
Regional specificity of RAR gamma isoforms in Xenopus development.
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RAR γ 亚型在非洲爪蟾发育中的区域特异性。
DOI：
10.1016/0925-4773(94)90028-0
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发表时间：
1994
影响因子：
2.6
通讯作者：
DeRobertis,EM
中科院分区：
文献类型：
--
作者：
Pfeffer,PL;DeRobertis,EM
所有的视黄酸受体(RAR)α，β，γ都有两种亚型，其功能尚不清楚。我们现在证明，至少对于RARγ来说，亚型在胚胎中的分布是不同的。RARγ1和RARγ2在头部区域表达，而RARγ2是在尾部区域表达的唯一异构体。具体地说，它在脊神经铰链中表达，这是尾芽中具有组织特性的区域。大剂量的维甲酸(RA)治疗会减少这一区域的表达。根据已知的RA在尾部区域的致畸作用，对结果进行了讨论。
All retinoic acid receptors (RARα, β, γ) have two isoforms, whose function is unknown. We now show that at least for RARγ, the isoforms are differentially distributed in the embryo. RARγ1 and RARγ2 are detected in the head region, whereas RARγ2 is the sole isoform expressed in the tail region. Specifically, it is expressed in the chordoneural hinge, a region of the tailbud that has organizing properties. Treatment with high doses of retinoic acid (RA) reduces expression in this region. The results are discussed in terms of the known teratogenic effects of RA in the tail region.