Research Facility for Radiobiological Studies at the University Proton Therapy Dresden
Research Facility for Radiobiological Studies at the University Proton Therapy Dresden
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DOI：
10.14338/ijpt-18-00008.1
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发表时间：
2018-06-01
影响因子：
1.7
通讯作者：
Luehr, Armin
中科院分区：
文献类型：
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作者：
Beyreuther, Elke;Baumann, Michael;Luehr, Armin
目的：为了更好地发挥质子放射治疗的作用，必须深入研究质子在正常组织和肿瘤组织中的生物学效应。关于可变相对生物学有效性沿着质子深度剂量分布的持续讨论（例如，Paganetti 2015），以及伴随治疗的给药，需要专门的体外试验准备转化为临床。因此，设置放射生物学研究和相应的剂量测定应建立，使在体外实验中的水平质子束和临床6 MV光子直线加速器（直线加速器）作为reference.Methods：实验质子束在德累斯顿大学质子治疗的特点是高光束的可用性和可靠性，在整个一天的平行患者治疗。对于细胞照射，可以形成均匀的10 - 3 - 10 cm 2的质子场与可选的扩展布拉格峰。一个充满水的幻影安装，允许精确定位不同的样品几何形状沿着的质子path.Results：深度-剂量分布在幻影和剂量均匀性超过不同的细胞样品的特征在于质子束和光子参考源。实施了每日质量保证方案，该方案提供了重要和可重现的体外实验所需的绝对剂量信息。细胞存活率测试实验进行了证明，这样的experiments.Conclusion的可行性：在德累斯顿大学质子治疗的实验室，临床相关条件的质子在体外实验已经实现。已建立的细胞体模和剂量测定有助于水环境中的辐照，并可转移到其他质子、光子和离子束设施。精确定位和轻松交换细胞样品、基于监测单元的剂量输送以及高光束可用性允许进行系统的体外实验。靠近放射治疗和放射生物学部门，为进一步的转化步骤提供了临床直线加速器和跨学科基础。
Purpose: In order to take full advantage of proton radiotherapy, the biological effect of protons in normal and tumor tissue should be investigated and understood in detail. The ongoing discussion on variable relative biological effectiveness along the proton depth dose distribution (eg, Paganetti 2015), and also the administration of concomitant treatments, demands dedicated in vitro trials that prepare the translation into the clinics. Therefore, a setup for radiobiological studies and the corresponding dosimetry should be established that enables in vitro experiments at a horizontal proton beam and a clinical 6 MV photon linear accelerator (Linac) as reference.Methods: The experimental proton beam at the University Proton Therapy Dresden is characterized by high beam availability and reliability throughout the day in parallel to patient treatment. For cell irradiation, a homogeneous 10 3 10 cm2 proton field with an optional spread-out Bragg-peak can be formed. A water-filled phantom was installed that allows for precise positioning of different sample geometries along the proton path.Results: Depth-dose profiles within the phantom and dose homogeneity over different cell samples were characterized for the proton beam and the photon reference source. A daily quality assurance protocol was implemented that provides absolute dose information required for significant and reproducible in vitro experiments. Cell survival test experiments were performed to demonstrate the feasibility of such experiments.Conclusion: In the experimental room of the University Proton Therapy Dresden, clinically relevant conditions for proton in vitro experiments have been realized. The established cell phantom and dosimetry facilitate irradiation in an aqueous environment and are transferable to other proton, photon and ion beam facilities. Precise positioning and easy exchange of cell samples, monitor unit-based dose delivery, and high beam availability allow for systematic in vitro experiments. The close vicinity to the radiotherapy and radiobiology departments provides access to clinical linacs and the interdisciplinary basis for further translational steps.