Polyclonal Epstein-Barr virus-associated lymphoproliferative disorder following autografting for chronic myeloid leukemia.
Polyclonal Epstein-Barr virus-associated lymphoproliferative disorder following autografting for chronic myeloid leukemia.
复制标题
慢性粒细胞白血病自体移植后多克隆 Epstein-Barr 病毒相关淋巴细胞增殖性疾病。
DOI：
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发表时间：
1995
影响因子：
4.8
通讯作者：
G. Phillips
中科院分区：
文献类型：
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作者：
J. Shepherd;R. Gascoyne;M. Barnett;J. Coghlan;G. Phillips
EB相关淋巴增生性疾病被描述为免疫缺陷状态的并发症，包括同种异体BMT。然而，在英语文献中只有一个报告自体移植后发生这种疾病。我们报告一位56岁的男性，接受自体骨髓移植治疗慢性粒细胞白血病，在骨髓移植后约30天出现了一种快速进行性淋巴组织增生性疾病，表现为典型的移植后淋巴组织增生性疾病的组织学特征，并伴有潜伏的EBV。采用皮质类固醇、阿昔洛韦和α-干扰素治疗，症状和体征迅速消退。在BMT后7个月没有淋巴组织增生性疾病的证据。它的结论是，EB病毒相关的淋巴组织增生性疾病可能是一种并发症，虽然是一种罕见的，强化治疗与自体干细胞支持。
Epstein-Barr-associated lymphoproliferative disorders have been described as complications of immunodeficiency states including allogeneic BMT. There is, however, only one report in the English language literature of such a disorder after autografting. We report a 56-year-old man undergoing autologous BMT for CML in whom a rapidly progressive lymphoproliferative disorder showing the histology of typical post-transplant lymphoproliferative disorder with latent EBV presence developed at approximately 30 days after BMT. Therapy with corticosteroids, acyclovir and alpha-interferon was instituted and led to prompt resolution of symptoms and signs. There was no evidence of lymphoproliferative disease at 7 months after BMT. It is concluded that EBV-associated lymphoproliferative disorders may be a complication, albeit a rare one, of intensive therapy with autologous stem cell support.