Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus
Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus
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DOI：
10.1093/cercor/bhx153
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发表时间：
2018-02-01
期刊：
影响因子：
3.7
通讯作者：
Maccaferri, Gianmaria
中科院分区：
文献类型：
--
作者：
Anstoetz, Max;Lee, Sun Kyong;Maccaferri, Gianmaria
与它们在成人新皮层中几乎消失相反，Cajal-Retzius细胞被认为在海马中存在更长时间。成熟海马的一个显著特征是它能够维持成年神经发生，而不是由其他皮质区域维持。在这里，我们已经调查了是否影响海马出生后神经发生的环境操作有一个平行的影响Cajal-Retzius细胞。我们使用多个小鼠报告细胞系来明确识别Cajal-Retzius细胞并量化其在产后发育期间的密度。我们发现，暴露于丰富的环境中增加了海马体中Cajal-Retzius细胞的持久性，但在相邻的皮质区域中没有。我们没有观察到类似的效果，小白蛋白表达的中间神经元，这表明发生的细胞类型特异性的过程。此外，我们没有检测到明显的变化，无论是在Cajal-Retzius细胞电生理或形态特征，与以前报道的动物没有暴露于丰富的条件相比。然而，Cajal-Retzius细胞到局部中间神经元的光遗传学触发的突触输出增强，与我们观察到的更高的Cajal-Retzius细胞密度一致。总之，我们的数据揭示了一种新形式的海马，细胞类型特异性，经验依赖性网络可塑性。我们认为，这种现象可能参与了富集依赖性增强海马出生后神经发生的调节。
In contrast to their near-disappearance in the adult neocortex, Cajal-Retzius cells have been suggested to persist longer in the hippocampus. A distinctive feature of the mature hippocampus, not maintained by other cortical areas, is its ability to sustain adult neurogenesis. Here, we have investigated whether environmental manipulations affecting hippocampal postnatal neurogenesis have a parallel impact on Cajal-Retzius cells. We used multiple mouse reporter lines to unequivocally identify Cajal-Retzius cells and quantify their densities during postnatal development. We found that exposure to an enriched environment increased the persistence of Cajal-Retzius cells in the hippocampus, but not in adjacent cortical regions. We did not observe a similar effect for parvalbumin-expressing interneurons, which suggested the occurrence of a cell type-specific process. In addition, we did not detect obvious changes either in Cajal-Retzius cell electrophysiological or morphological features, when compared with what previously reported in animals not exposed to enriched conditions. However, optogenetically triggered synaptic output of Cajal-Retzius cells onto local interneurons was enhanced, consistent with our observation of higher Cajal-Retzius cell densities. In conclusion, our data reveal a novel form of hippocampal, cell type-specific, experience-dependent network plasticity. We propose that this phenomenon may be involved in the regulation of enrichment-dependent enhanced hippocampal postnatal neurogenesis.