Blockade by amino acid antagonists of neuronal excitation mediated by the pyramidal tract.
Blockade by amino acid antagonists of neuronal excitation mediated by the pyramidal tract.
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氨基酸拮抗剂阻断锥体束介导的神经元兴奋。
DOI：
10.1113/jphysiol.1976.sp011363
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
T. Stone
中科院分区：
文献类型：
--
作者：
T. Stone
1.本实验观察了麻醉大鼠楔核细胞对谷氨酸和氨基酸拮抗剂的反应.通过微离子电渗法施用的1-羟基-3-氨基-吡咯烷酮-2（HA-966）和谷氨酸二乙酯减少了神经元的谷氨酸兴奋。HA-966比谷氨酸二乙酯对更多的细胞具有抑制作用，并且更有效。HA-966不影响对乙酰胆碱的兴奋性反应。刺激大脑皮层诱发皮层神经细胞的锋电位活动。研究了可能归因于细胞单突触激活的尖峰。锥体束是已知的唯一能够短潜伏期激活背柱核神经元的离皮质通路。HA-966可逆地阻断了40个单位中28个（70%）的诱发活动，其中诱导了单突触诱发的棘波。结果提示锥体束神经元释放的神经递质可能是一种兴奋性氨基酸。
1.The responses to glutamate and amino acid antagonists of cells in the cuneate nucleus of anaesthetized rats have been examined.2. 1‐hydroxy‐3‐amino‐pyrrolidone‐2 (HA‐966) and glutamic acid diethylester applied by micro‐iontophoresis reduced glutamate excitation of the neurons. HA‐966 WAS EFFECTIVE ON MORE CELLS THAN GLUTAMIC ACID DIETHYLESTER AND WAS MORE POTENT. HA‐966 DID NOT AFFECT EXCITATORY RESPONSES TO ACETYLCHOLINE.3. Spike activity of cuneate cells was evoked by stimulating the cerebral cortex. Spikeswhich could be attributed to monosynaptic activation of the cells were studied. The pyramidal tract is the only corticofugal pathway known to be capable of short latency activation of dorsal column nucleus neurones.4. HA‐966 reversibly blocked the evoked activity in twenty‐eight (70%) of forty units in which monosynaptically evoked spikes were induced.5. The results raise the possibility that the neurotransmitter released by neurones of the pyramidal tract may be an excitatory amino acid.