Imaging brain plasticity during motor skill learning
Imaging brain plasticity during motor skill learning
复制标题
DOI：
10.1006/nlme.2002.4091
复制
发表时间：
2002-11-01
影响因子：
2.7
通讯作者：
Karni, A
中科院分区：
文献类型：
--
作者：
Ungerleider, LG;Doyon, J;Karni, A
在过去的十年里，寻找调节技能运动行为增量获得的神经基质一直是大量动物和人类研究的焦点。然而，关于在学习的不同阶段运动系统中发生的动态神经变化，我们知道的要少得多。在本文中，我们回顾了最近的研究结果，主要是从我们自己的工作，使用功能磁共振成像，这表明：（i）顺序手指运动的学习产生了一个缓慢发展的重组在初级运动皮层（MI）在几周的过程中，和（ii）在M1的这种变化之后，在小脑，纹状体，和其他运动相关的皮层区域在几天的过程中更动态，快速的变化。我们还简要回顾了神经生理学和心理物理学证据的巩固运动技能，我们提出了一个工作假设，其潜在的神经基板在运动序列学习。(C)2002 Elsevier Science（美国）。
The search for the neural substrates mediating the incremental acquisition of skilled motor behaviors has been the focus of a large body of animal and human studies in the past decade. Much less is known, however, with regard to the dynamic neural changes that occur in the motor system during the different phases of learning. In this paper, we review recent findings, mainly from our own work using fMRI, which suggest that: (i) the learning of sequential finger movements produces a slowly evolving reorganization within primary motor cortex (M I) over the course of weeks and (ii) this change in M1 follows more dynamic, rapid changes in the cerebellum, striatum, and other motor-related cortical areas over the course of days. We also briefly review neurophysiological and psychophysical evidence for the consolidation of motor skills, and we propose a working hypothesis of its underlying neural substrate in motor sequence learning. (C) 2002 Elsevier Science (USA).