NF-κB Links Keratinocytes and Lymphocytes in the Pathogenesis of Psoriasis
NF-κB Links Keratinocytes and Lymphocytes in the Pathogenesis of Psoriasis
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DOI：
10.2174/187221309787158399
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Tsuruta, Daisuke
中科院分区：
文献类型：
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作者：
Tsuruta, Daisuke
银屑病是一种常见的慢性复发性自身免疫性皮肤病。其临床特征为边界清晰的片状斑块，表面覆盖银鳞片。在组织学上，其特征在于表皮厚度增加、乳头延长和由淋巴细胞、巨噬细胞和中性粒细胞组成的中度炎性浸润。银屑病的组织学标志是Munro微脓肿，其是多形核白细胞在角质层中的积聚。该病的发病机制至今仍是个谜，但有遗传易感性、角质形成细胞功能异常或免疫功能紊乱，特别是T细胞紊乱的假说。在过去的几十年里，关于“角质形成细胞依赖性”病理学与“免疫细胞依赖性”病理学的争论一直存在。到目前为止，已经有一些银屑病的啮齿动物模型。其中，Rebholz等人最近发表的文章非常有趣，因为它们解释了角质形成细胞和淋巴细胞之间的串扰：现在已有证据表明，虽然角质形成细胞或淋巴细胞中的异常NF-κ B激活无法重现银屑病样组织学，但两者中的这种激活重现了银屑病病理学的所有上述“标志”。因此，NF-κ B B很可能是T细胞介导和角质形成细胞介导的银屑病发病机制之间的联系。本文还讨论了一些与该领域相关的最新专利。
Psoriasis is a common, chronic and relapsing autoimmune skin disease. Clinical characteristics of this disease are sharply-demarcated erythematous plaques covered with silver scales. Histologically, it is characterized by increased epidermal thickness, elongated papillae, and a moderate inflammatory infiltrate composed of lymphocytes, macrophages and neutrophils. The histological hallmark of psoriasis is Munro's microabscess, which is an accumulation of polymorphonuclear leukocytes in the keratinous layer. The mechanism of this disease is still an enigma, but genetic susceptibility, abnormal function of keratinocytes, or immunological disturbance, especially in T cells, are postulated. Over the past decades, there have been arguments about "keratinocyte-dependent" pathology as opposed to "immunocyte-dependent" pathology. Thus far, there have been some rodent models for psoriasis. Among them, the recent article from Rebholz et al. is quite intriguing because they explain the crosstalk between keratinocytes and lymphocytes: now evidence has been presented that while the aberrant NF-kappa B activation in either keratinocytes or lymphocytes could not reproduce psoriasis-like histology, such activation in both reproduced all of the aforementioned "hallmarks" of psoriasis pathology. Therefore, NF-kappa B may well act as a link between the T cell-mediated and keratinocyte-mediated arguments concerning the pathogenesis of psoriasis. This article also discusses some recent patent related to the field.