Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.
Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.
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DOI：
10.1038/bmt.2016.130
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发表时间：
2016-07
影响因子：
4.8
通讯作者：
Carreras E
中科院分区：
文献类型：
--
作者：
Mohty M;Malard F;Abecassis M;Aerts E;Alaskar AS;Aljurf M;Arat M;Bader P;Baron F;Bazarbachi A;Blaise D;Ciceri F;Corbacioglu S;Dalle JH;Dignan F;Fukuda T;Huynh A;Masszi T;Michallet M;Nagler A;NiChonghaile M;Okamoto S;Pagliuca A;Peters C;Petersen FB;Richardson PG;Ruutu T;Savani BN;Wallhult E;Yakoub-Agha I;Duarte RF;Carreras E
正弦阻塞综合征，也称为静脉闭塞性疾病 (SOS/VOD)，是造血细胞移植后可能出现的一种潜在危及生命的并发症。尽管大多数患者的 SOS/VOD 在几周内逐渐缓解，但最严重的形式会导致多器官功能障碍，并与高死亡率 (>80%) 相关。因此，必须特别注意，以便及早发现 SOS/VOD，特别是因为药物现已被证明是有效的并已获得治疗许可。不幸的是，目前的标准缺乏敏感性和特异性，使得 SOS/VOD 的早期识别和严重性评估变得困难。这项工作的目的是代表欧洲血液和骨髓移植学会提出一个新的诊断定义以及成人患者 SOS/VOD 的严重程度分级系统。
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.