Differences in the aggressiveness of prostate cancer among Korean, Caucasian, and African American men: A retrospective cohort study of radical pro statectomy
Differences in the aggressiveness of prostate cancer among Korean, Caucasian, and African American men: A retrospective cohort study of radical pro statectomy
复制标题
DOI：
10.1016/j.urolonc.2015.08.004
复制
发表时间：
2016-01-01
影响因子：
2.7
通讯作者：
Ro, Jae Y.
中科院分区：
文献类型：
--
作者：
Jeong, In Gab;Dajani, Daoud;Ro, Jae Y.
目的：我们的目的是比较韩国和西方的根治性前列腺癌切除术治疗的临床局限性前列腺癌（PCa）的病理侵袭性，通过分析来自韩国首都（首尔）和美国的代表性医院的数据，（华盛顿，DC）。我们对1,939例在牙山医疗中心和华盛顿医院中心接受根治性前列腺癌切除术的患者进行了回顾性队列研究。调整混杂的临床变量后，我们使用多变量logistic回归分析，以评估PCa.Results的侵略性的差异：我们分析了1,152韩国，473高加索人，和314 AA患者。韩国和西方患者在手术年龄、术前前列腺特异性抗原水平和临床分期方面存在显着差异（P < 0.001）。总体而言，高级别PCa（Gleason评分>= 8）在韩国（19.4%）比AA（6.1%）或白人（5.5%）患者更常见（P < 0.001）。韩国患者中晚期PCa（pT 3或更高）的发生率（34.8%）高于AA（18.2%）或白人（13.3%）患者（P < 0.001）。在校正了年龄、前列腺特异性抗原、前列腺体积和临床分期后，多变量logistic回归分析显示，韩国男性有高级别PCa的高风险。（韩国人与高加索人，比值比[OR] = 3.48，P < 0.001;韩国与AA，OR = 3.14，P < 0.001）或晚期PCa（韩国人对高加索人，OR = 2.40，P < 0.001;韩国人对AA，OR = 1.59，P = 0.009）。韩国男性和西方男性的PCa攻击性存在差异。高级别或晚期PCa的发生率在韩国男性中较高。(C)2016 Elsevier Inc. All rights reserved.
Purpose: We aimed to compare the pathologic aggressiveness of clinically localized prostate cancer (PCa) treated by radical prostatectomy in Korean and Western (Caucasian and African American [AA]) men by analyzing data from representative hospitals in the capitals of Korea (Seoul) and the United States (Washington, DC).Methods: We performed a retrospective cohort study of 1,939 patients who underwent radical prostatectomy for clinically localized PCa in the Asan Medical Center and Washington Hospital Center. After adjusting for confounding clinical variables, we used multivariate logistic regression analysis to assess differences in the aggressiveness of PCa.Results: We analyzed 1,152 Korean, 473 Caucasian, and 314 AA patients. There were significant differences between Korean and Western patients in terms of age at surgery, preoperative levels of prostate-specific antigen, and clinical stage (P < 0.001). Overall, high-grade PCa (Gleason score >= 8) was more common in Korean (19.4%) than in AA (6.1%) or Caucasian (5.5%) patients (P < 0.001). The incidence of advanced-stage PCa (pT3 or higher) was higher in Korean (34.8%) than in AA (18.2%) or Caucasian (13.3%) patients (P < 0.001). After adjusting for age, prostate-specific antigen, prostate volume, and clinical stage, multivariate logistic regression analysis showed that Korean men had a high risk of high-grade PCa (Korean vs. Caucasian, odds ratio [OR] = 3.48, P < 0.001; Korean vs. AA, OR = 3.14, P < 0.001) or advanced-stage PCa (Korean vs. Caucasian, OR = 2.40, P < 0.001; Korean vs. AA, OR = 1.59, P = 0.009) than Western men.Conclusions: There are differences in PCa aggressiveness between Korean and Western men. The incidence of high-grade or advanced-stage PCa is higher in Korean men. (C) 2016 Elsevier Inc. All rights reserved.