Direct demonstration of macula densa-mediated renin secretion.
Direct demonstration of macula densa-mediated renin secretion.
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DOI：
10.1126/science.3306925
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发表时间：
1987-09
期刊：
影响因子：
56.9
通讯作者：
O. Skøtt;J. Briggs
中科院分区：
文献类型：
--
作者：
O. Skøtt;J. Briggs
一种体外方法已被用来检查肾小球旁器官的肾素分泌是否受到黄斑致密处管状液氯化钠浓度变化的影响。显微解剖家兔肾小球旁器，灌注含黄斑致密的小管段，同时灌注整个肾小球旁器，收集液体进行肾素测定。在该制剂中，消除了肾神经和局部血流动力学效应的影响，黄斑致密处小管氯化钠浓度的降低导致肾素释放率的迅速刺激。
An in vitro method has been used to examine whether secretion of renin from the juxtaglomerular apparatus is affected by changes in the sodium chloride concentration of the tubular fluid at the macula densa. Single juxtaglomerular apparatuses were microdissected from rabbits and the tubule segment containing the macula densa was perfused, while simultaneously the entire juxtaglomerular apparatus was superfused, and the fluid was collected for renin measurement. In this preparation, in which influences from renal nerves and local hemodynamic effects are eliminated, a decrease in the tubular sodium chloride concentration at the macula densa results in a prompt stimulation of the renin release rate.