Data on carotid intima-media thickness and lipoprotein subclasses in type 1 diabetes from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC).
Data on carotid intima-media thickness and lipoprotein subclasses in type 1 diabetes from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC).
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DOI：
10.1016/j.dib.2015.11.036
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发表时间：
2016-03
期刊：
影响因子：
1.2
通讯作者：
DCCT/EDIC Research Group
中科院分区：
文献类型：
--
作者：
Basu A;Jenkins AJ;Zhang Y;Stoner JA;Klein RL;Lopes-Virella MF;Timothy Garvey W;Lyons TJ;DCCT/EDIC Research Group
1型糖尿病（T1 DM）与大血管并发症的风险增加有关。我们研究了参加糖尿病控制和并发症试验（DCCT）的T1 DM成人（n=455）的血清常规脂质和核磁共振（NMR）测定的脂蛋白亚类与颈动脉内膜中层厚度（IMT）的纵向相关性。在DCCT基线（1983-89）收集血脂和脂蛋白数据，并与DCCT观察随访期间超声检查确定的颈总动脉和颈内动脉IMT相关，EDIC干预和并发症流行病学（EDIC）研究，EDIC“第1年”（199-1996）和EDIC“第6年”（1998-2000）。本文包含了DCCT基线脂蛋白谱（基于NMR的VLDL和乳糜微粒、IDL/LDL和HDL亚类以及“常规”总、LDL-、HDL-、非HDL-胆固醇和甘油三酯）与EDIC第1年和第6年颈动脉IMT的相关性数据，按性别分层。这些数据是对我们原始研究文章的补充，该文章描述了DCCT基线血脂和脂蛋白谱与EDIC第12年颈动脉IMT的详细相关性（Basu等，出版中）。
Type 1 diabetes (T1DM) is associated with increased risk of macrovascular complications. We examined longitudinal associations of serum conventional lipids and nuclear magnetic resonance (NMR)-determined lipoprotein subclasses with carotid intima-media thickness (IMT) in adults with T1DM (n=455) enrolled in the Diabetes Control and Complications Trial (DCCT). Data on serum lipids and lipoproteins were collected at DCCT baseline (1983–89) and were correlated with common and internal carotid IMT determined by ultrasonography during the observational follow-up of the DCCT, the Epidemiology of Diabetes Interventions and Complications (EDIC) study, at EDIC ‘Year 1’ (199–1996) and EDIC ‘Year 6’ (1998–2000). This article contains data on the associations of DCCT baseline lipoprotein profiles (NMR-based VLDL & chylomicrons, IDL/LDL and HDL subclasses and ‘conventional’ total, LDL-, HDL-, non-HDL-cholesterol and triglycerides) with carotid IMT at EDIC Years 1 and 6, stratified by gender. The data are supplemental to our original research article describing detailed associations of DCCT baseline lipids and lipoprotein profiles with EDIC Year 12 carotid IMT (Basu et al. in press).