Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program
Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program
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DOI：
10.1016/j.neuron.2013.04.009
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发表时间：
2013-06-05
期刊：
影响因子：
16.2
通讯作者：
Okamoto, Hitoshi
中科院分区：
文献类型：
--
作者：
Aoki, Tazu;Kinoshita, Masae;Okamoto, Hitoshi
对习得行为的长期联想记忆进行编码是一项基本的大脑功能。然而，我们对脊椎动物皮层的行为如何稳定地巩固和恢复还知之甚少。我们对斑马鱼进行厌恶强化学习训练，并在检索学到的反应过程中测量了斑马鱼整个大脑的钙信号。训练后立即不活动的背侧端脑的离散区域在第二天变得活跃。对所识别区域的分析表明，它对于长期记忆提取是特定且必需的，并且包含对学习刺激产生的电生理反应。当行为规则改变时，观察到整个端脑的功能图谱发生快速的空间变化。这些结果表明，可以在斑马鱼体内行为的全脑范围内研究对习得行为的长期记忆的检索。此外，研究结果表明，强化学习过程中巩固的记忆痕迹可以快速修改。
The encoding of long-term associative memories for learned behaviors is a fundamental brain function. Yet, how behavior is stably consolidated and retrieved in the vertebrate cortex is poorly understood. We trained zebrafish in aversive reinforcement learning and measured calcium signals across their entire brain during retrieval of the learned response. A discrete area of dorsal telencephalon that was inactive immediately after training became active the next day. Analysis of the identified area indicated that it was specific and essential for long-term memory retrieval and contained electrophysiological responses entrained to the learning stimulus. When the behavioral rule changed, a rapid spatial shift in the functional map across the telencephalon was observed. These results demonstrate that the retrieval of long-term memories for learned behaviors can be studied at the whole-brain scale in behaving zebrafish in vivo. Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning.