PROJECTIONS FROM THE AMYGDALA TO BASOVENTRAL AND MEDIODORSAL PREFRONTAL REGIONS IN THE RHESUS-MONKEY
PROJECTIONS FROM THE AMYGDALA TO BASOVENTRAL AND MEDIODORSAL PREFRONTAL REGIONS IN THE RHESUS-MONKEY
复制标题
DOI：
10.1002/cne.903000409
复制
发表时间：
1990-10-22
影响因子：
2.5
通讯作者：
DEOLMOS, J
中科院分区：
文献类型：
--
作者：
BARBAS, H;DEOLMOS, J
用辣根过氧化物酶或荧光染料逆行追踪法研究了13只恒河猴杏仁核向基底腹侧和背内侧前额叶皮质的同侧投射来源。注射示踪剂的基底腹侧区包括眶周皮质和前皮质，眶区13、11和12，外侧区12和腹侧区46。中背区域包括内侧区域25、32、14和背侧区域8的部分。上述部位代表了两个架构系列的皮质内的区域，根据其解剖位置被称为基底腹侧或中背侧。每个系列由显示出层数逐渐增加的区域组成，并且它们在从具有初始层状组织的尾侧眶和内侧边缘皮质朝向真层化的弓状周皮质的方向上的轮廓（Barbas和Pandya，J.Comp.Neurol. 286：353-375，“89）。投射到前额叶皮质的标记神经元位于基底外侧、基底内侧（也称为副基底）、外侧和腹侧皮质核，以及前杏仁核和杏仁核区。标记的神经元的分布不同的定量和定性取决于注射部位是否在basoventral或mediodorsal前额叶皮质。尾侧眼眶注射的病例在杏仁核中有最多的标记神经元，其次是位于中腹侧的皮质注射的病例。后者的杏仁核投射很大一部分来自基底内侧核。外侧杏仁核发出一个强大的投影到最不architectonically分化的眼眶perialocortex，和一个较弱的投影到相邻的眼眶proisocortex区域，但似乎没有项目，无论是内侧proisocortex网站或更分化的腹外侧或背外侧前额叶皮质。此外，从杏仁核到不同的前额叶皮质的投射来源也存在地形差异。这些差异与传入杏仁核神经元的轴突的目的地basoventral或mediodorsal前额叶皮质和/或与他们的投影到不同程度的层状组织内的basoventral或mediodorsal部门的地区。起源于基底外侧核的投射观察到最清晰的地形图。结果表明，最不architectonically分化的基底部位位于尾侧眶额区，其次是可比的内侧区位于腹侧的内侧表面，收到最强和最广泛的预测杏仁核。内侧proisocortices位于更多的背侧和尾侧只收到了一些预测杏仁核。此外，在基底腹侧和中背侧区域内具有高度层状组织的区域（尾侧区域46和8）收到了很少的和地形限制的杏仁核投射。
The sources of ipsilateral projections from the amygdala to basoventral and mediodorsal prefrontal cortices were studied with retrograde tracers (horseradish peroxidase or fluorescent dyes) in 13 rhesus monkeys. The basoventral regions injected with tracers included the orbital periallocortex and proisocortex, orbital areas 13, 11, and 12, lateral area 12, and ventral area 46. The mediodorsal regions included portions of medial areas 25, 32, 14, and dorsal area 8. The above sites represent areas within two architectonic series of cortices referred to as basoventral or mediodorsal on the basis of their anatomic location. Each series consists of areas that show a gradual increase in the number of layers and their delineation in a direction from the caudal orbital and medial limbic cortices, which have an incipient laminar organization, towards the eulaminated periarcuate cortices (Barbas and Pandya, J. Comp. Neurol. 286:353-375, ''89). Labeled neurons projecting to the prefrontal cortex were found in the basolateral, basomedial (also known as accessory basal), lateral, and ventral cortical nuclei, and in the anterior amygdaloid and amygdalopiriform areas. The distribution of labeled neurons differed both quantitatively and qualitatively depending on whether the injection sites were in basoventral or mediodorsal prefrontal cortices. Cases with caudal orbital injections had the most labeled neurons in the amygdala, followed by cases with injections in cortices situated medioventrally. The latter received a high proportion of their amygdaloid projections from the basomedial nucleus. The lateral amygdaloid nucleus sent a robust projection to the least architectonically differentiated orbital periallocortex, and a weaker projection to the adjoining orbital proisocortical regions, but did not appear to project to either medial proisocortical sites or to the more differentiated ventrolateral or dorsolateral prefrontal cortices. In addition, there were topographical differences in the origin of projections from one amygdaloid nucleus directed to various prefrontal cortices. These differences were correlated either with the destination of the axons of afferent amygdaloid neurons to basoventral or to mediodorsal prefrontal cortices and/or with their projection to areas with varying degrees of laminar organization within the basoventral or mediodorsal sector. The clearest topography was observed for projections originating in the basolateral nucleus. The results indicate that the least architectonically differentiated basal sites situated in the caudal orbitofrontal region, followed by the comparable medial areas situated ventrally on the medial surface, received the strongest and most widespread projections from the amygdala. Medial proisocortices situated more dorsally and caudally received only a few projections from the amygdala. In addition, areas with a high degree of laminar organization (caudal areas 46 and 8) within both basoventral and mediodorsal regions received few and topographically restricted amygdaloid projections.