Analysis of the mammalian talin2 gene TLN2
Analysis of the mammalian talin2 gene TLN2
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DOI：
10.1006/bbrc.2001.5497
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发表时间：
2001-09-07
影响因子：
3.1
通讯作者：
Critchley, DR
中科院分区：
文献类型：
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作者：
Monkley, SJ;Pritchard, CA;Critchley, DR
我们已经利用基因组和EST数据库来组装人talin 2（TLN 2）基因的序列。Talin 2蛋白在其整个长度上在大小和序列上与Talin 1相似（74%同一性，86%相似性）。主要差异在于（i）基因的大小，由于内含子大小的差异，TLN 2基因>200 kb，而TLN 1基因约为30 kb，尽管内含子/外显子边界（除两个外）是严格保守的;（ii）表达模式，TLN 1产生类似于在所有组织中观察到的8 kb mRNA，而MAT在心脏中产生具有最高水平的多种转录物。(C)北京：科学出版社.
We have utilised genomic and EST databases to assemble the sequence of the human talin2( TLN2) gene. Talin2 protein is similar in size and sequence to talin1 throughout its length (74% identity, 86% similarity). The major differences are in (i) the size of the genes, the TLN2 gene is >200 kb compared with similar to 30 kb for TLN1 due to a difference in intron size, although intron/exon boundaries, with the exception of two, are strictly conserved; (ii) the expression patterns, TLN1 gives rise to an similar to8-kb mRNA which is observed in all tissues, whereas MAT gives rise to multiple transcripts with the highest levels in heart. (C) 2001 Academic Press.