OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone-Related Deaths
OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone-Related Deaths
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DOI：
10.1038/clpt.2010.127
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发表时间：
2010-09-01
影响因子：
6.7
通讯作者：
Osselton, D.
中科院分区：
文献类型：
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作者：
Bunten, H.;Liang, W. J.;Osselton, D.
美沙酮是一种因其治疗海洛因成瘾的有效性而受到重视的药物;然而，多年来报告了许多与使用美沙酮有关的致命中毒事件。我们研究了CYP 2B 6和μ阿片受体（OPRM 1）基因变异与美沙酮中毒易感性之间的关系。基因组DNA提取自40个人的死亡归因于美沙酮中毒的死后全血。通过SNP基因分型确定CYP 2B 6 *4、*9和 *6等位基因和OPRM 1 A118 G变体的存在。CYP 2B 6 *4、*9和 *6等位基因与死后血中较高的美沙酮浓度相关（P
Methadone is a medication valued for its effectiveness in the treatment of heroin addiction; however, many fatal poisonings associated with its use have been reported over the years. We have examined the association between CYP2B6 and mu-opioid receptor (OPRM1) gene variations and apparent susceptibility to methadone poisoning. Genomic DNA was extracted from postmortem whole blood of 40 individuals whose deaths were attributed to methadone poisoning. The presence of CYP2B6*4,*9, and *6 alleles and the OPRM1 A118G variant was determined by SNP genotyping. CYP2B6*4, *9, and *6 alleles were found to be associated with higher postmortem methadone concentrations in blood (P