Patient-Reported Outcomes Measurement Information System (PROMIS) instruments among individuals with symptomatic knee osteoarthritis: a cross-sectional study of floor/ceiling effects and construct validity.
Patient-Reported Outcomes Measurement Information System (PROMIS) instruments among individuals with symptomatic knee osteoarthritis: a cross-sectional study of floor/ceiling effects and construct validity.
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有症状的膝盖骨关节炎的患者报告的结果测量信息系统（Promis）仪器：地板/天花板效应和构造有效性的横断面研究。
DOI：
10.1186/s12891-015-0715-y
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发表时间：
2015-09-14
影响因子：
2.3
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Driban JB;Morgan N;Price LL;Cook KF;Wang C
患者报告结果测量信息系统（PROMIS）工具的心理测量特性已在一些一般和临床样本中进行了探索。然而，没有研究评估这些措施在有症状的膝关节骨关节炎（KOA）患者中的心理测量功能。该项目的目的是评估该人群中四种PROMIS措施的结构（结构）有效性和下限/上限效应。我们对一项比较太极和物理疗法的随机试验的基线数据进行了二次分析。参与者完成了四个PROMIS静态短格式工具（即，焦虑、抑郁、身体功能和疼痛干扰）以及六项评估疼痛、功能和心理健康的经过充分验证的（传统）指标。我们计算了描述性统计量和参与者的百分比得分的最低（下限）和最高（上限）的PROMIS和传统的措施可能的分数。我们还使用斯皮尔曼等级相关系数估计了PROMIS评分和遗留指标评分之间的相关性。分析了204名参与者的数据。样本的平均年龄为60岁; 70%为女性。PROMIS焦虑和抑郁有下限效应，分别有17%和24%的参与者得分最低。PROMIS焦虑和抑郁评分与一般心理健康状况的相关性最强，包括压力（感知压力量表，r ≥ 0.65）和抑郁（贝克抑郁指数-II，r = 0.70）。PROMIS疼痛干扰评分与全身疼痛（简表36躯体疼痛，r =-0.73）和身体健康（简表36身体健康总结，r =-0.73）指标的相关性最强;与其他遗留指标的相关性较低，包括与WOMAC膝关节特异性疼痛（r = 0.47）。PROMIS身体功能评分与简表36身体功能评分（r = 0.79）的相关性强于与其他遗留指标评分的相关性。四种PROMIS静态-短形式在有症状的膝关节骨关节炎患者中表现良好，与传统指标相关。PROMIS焦虑和抑郁症针对一般心理健康（例如，压力、抑郁）和PROMIS疼痛干预和身体功能静态-简短形式针对有症状的膝关节骨关节炎参与者的全身结果。如果需要区分这些结果水平非常低的患者，应考虑PROMIS焦虑和抑郁评分中的下限效应。Clinicaltrials.gov NCT01258985。注册日期2010年12月10日本文的在线版本（doi：10.1186/s12891-015-0715-y）包含补充材料，授权用户可以使用。
The psychometric properties of Patient Reported Outcomes Measurement Information System (PROMIS) instruments have been explored in a number of general and clinical samples. No study, however, has evaluated the psychometric function of these measures in individuals with symptomatic knee osteoarthritis (KOA). The aim of this project was to evaluate the construct (structural) validity and floor/ceiling effects of four PROMIS measures in this population. We conducted a secondary analysis of baseline data from a randomized trial comparing Tai Chi and physical therapy. Participants completed four PROMIS static short-form instruments (i.e., Anxiety, Depression, Physical Function, and Pain Interference) as well as six well-validated (legacy) measures that assess pain, function, and psychological health. We calculated descriptive statistics and percentages of participants scoring the minimum (floor) and maximum (ceiling) possible scores for PROMIS and legacy measures. We also estimated the association between PROMIS scores and scores on legacy measures using Spearman’s rank correlations coefficients. Data from 204 participants were analyzed. Mean age of the sample was 60 years; 70 % were female. The PROMIS Anxiety and Depression had floor effects with 17 and 24 % of participants scoring the minimum, respectively. PROMIS Anxiety and Depression scores had strongest associations with general mental health, including stress (Perceived Stress Scale, r ≥ 0.65) and depression (Beck Depression Index-II, r = 0.70). PROMIS Pain Interference scores correlated most strongly with measures of whole body pain (Short-Form 36 Bodily Pain, r = −0.73) and physical health (Short-Form 36 Physical-Component Summary, r = −0.73); their correlations were lower with other legacy measures, including with the WOMAC knee-specific pain (r = 0.47). PROMIS Physical Function scores had stronger associations with scores on the Short-Form 36 Physical Function (r = 0.79) than with scores on other legacy measures. The four PROMIS static-short forms performed well among individuals with symptomatic knee osteoarthritis as evidenced in correlations with legacy measures. PROMIS Anxiety and Depression target general mental health (e.g., stress, depression), and PROMIS Pain Interference and Physical Function static-short forms target whole-body outcomes among participants with symptomatic knee osteoarthritis. Floor effects in the PROMIS Anxiety and Depression scores should be considered if needing to distinguish among patients with very low levels of these outcomes. Clinicaltrials.gov NCT01258985. Registered 10 December 2010 The online version of this article (doi:10.1186/s12891-015-0715-y) contains supplementary material, which is available to authorized users.