18F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly
18F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly
复制标题
DOI：
10.1021/nn200298y
复制
发表时间：
2011-04-01
期刊：
影响因子：
17.1
通讯作者：
Li, Fuyou
中科院分区：
文献类型：
--
作者：
Liu, Qian;Sun, Yun;Li, Fuyou
一种新的方法，稀土阳离子辅助配体组装已被开发，以提供上转换纳米荧光粉与T-1增强的磁共振（MR），放射性和有针对性的识别性能，使这些纳米粒子的潜在候选人的多模态生物成像。通过透射电子显微镜、X射线粉末衍射、X射线光电子能谱、质子核磁共振、傅里叶变换红外光谱、能量色散X射线分析、这种表面修饰方法的多功能性，用于纳入功能分子和制造氟-18标记的磁性-上转换纳米磷光体作为多模式生物探针已经通过靶向细胞成像、体内上转换发光、MR成像和全身小动物的正电子发射断层摄影成像得到证实。
A novel method of rare-earth cation assisted ligand assembly has been developed to provide upconversion nanophosphors with T-1-enhanced magnetic resonance (MR), radioactivity, and targeted recognition properties, making these nanoparticles potential candidates for multimodal bioimaging. The process of modifying the surface of the nanophosphors has been confirmed by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, energy-dispersive X-ray analysis, and so on. The versatility of this surface modification approach for incorporating functional molecules and fabricating fluorine-18-labeled magnetic-upconversion nanophosphors as multimodal bioprobes has been demonstrated by targeted cell imaging, In vivo upconversion luminescence, MR Imaging, and positron emission tomography imaging of whole-body small animals.