Cell surface molecules and tumor metastasis. Regulation of metastatic phenotypic diversity.
Cell surface molecules and tumor metastasis. Regulation of metastatic phenotypic diversity.
复制标题
细胞表面分子与肿瘤转移。
DOI：
10.1016/0014-4827(84)90696-7
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发表时间：
1984
影响因子：
3.7
通讯作者：
Nicolson,GL
中科院分区：
文献类型：
--
作者：
Nicolson,GL
转移性肿瘤细胞的特征是细胞表面和其他特性的定量改变，这些特性赋予了这些细胞在继发部位侵袭、传播、植入、存活和生长的能力。转移也由多种宿主因素决定，这些因素可以阻止、允许甚至刺激转移过程。恶性肿瘤中多样化细胞亚群的出现保证了一些细胞最终会高度转移，导致肿瘤向最有利于生存和生长的特征发展。未知的机制似乎刺激然后控制肿瘤细胞亚群的表型多样化。这些机制可能被单独影响恶性肿瘤细胞的遗传（突变）和/或表观遗传（非突变）修饰所改变。
Metastatic tumor cells are characterized by quantitative alterations in cell surface and other properties that confer to these cells their abilities to invade, disseminate, implant, survive and grow at secondary sites. Metastasis is also determined by a variety of host factors that prevent, allow or even stimulate metastatic processes. The emergence of diversified cell subpopulations in malignant tumors insures that some cells will ultimately become highly metastatic, resulting in tumor progression towards characteristics which are the most favorable for survival and growth. Unknown mechanisms appear to stimulate and then to control phenotypic diversification of tumor cell subpopulations. These mechanisms may be altered by genetic (mutational) and/or epigenetic (non-mutational) modifications that individually influence cells within a malignant neoplasm.