Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression
Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression
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DOI：
10.1111/ajt.15869
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发表时间：
2020-03-31
影响因子：
8.8
通讯作者：
Chen, Gang
中科院分区：
文献类型：
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作者：
Zhu, Lan;Xu, Xizhen;Chen, Gang
目前爆发的2019冠状病毒病（COVID-19）在全球引起了极大的关注，但其对移植受者的影响尚不清楚。我们在此报告首例肾移植受者确诊COVID-19肺炎的临床特征和治疗过程。这是一位52岁的男性，12年前接受了肾移植。他的总体临床特征（症状、实验室检查和胸部CT）与非移植COVID-19患者相似。经过包括减少免疫抑制剂使用和低剂量甲基强的松龙治疗的治疗方案，该长期免疫抑制患者的COVID-19肺炎成功康复。这一有效治疗的病例对未来其他移植患者合并COVID-19肺炎的治疗具有参考价值。
The current outbreak of Coronavirus Disease 2019 (COVID-19) has raised great concern worldwide, but its impact on transplant recipients is unknown. We report here the clinical features and therapeutic course of the first reported renal transplant recipient with confirmed COVID-19 pneumonia. This is a 52-year-old man who received kidney transplantation 12 years ago. His overall clinical characteristics (symptoms, laboratory examinations, and chest CT) were similar to those of non-transplanted COVID-19 patients. Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia.