Chronic leg ulceration in homozygous sickle cell disease: the role of venous incompetence
Chronic leg ulceration in homozygous sickle cell disease: the role of venous incompetence
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DOI：
10.1046/j.1365-2141.2002.03833.x
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发表时间：
2002-11-01
影响因子：
6.5
通讯作者：
Serjeant, GR
中科院分区：
文献类型：
--
作者：
Clare, A;FitzHenley, M;Serjeant, GR
慢性腿部溃疡是牙买加纯合子镰状细胞病（SS）患者发病的常见原因。溃疡在卧床休息时愈合更快，长时间站立时恶化，表明静脉高压在其持续性中的作用。在牙买加队列研究中，通过多普勒检测SS患者和血红蛋白（AA）基因型正常的匹配对照组的静脉功能，验证了这一假设。SS疾病[137/183（75%）]中静脉功能不全的发生率显著高于非妊娠AA对照[53/137（39%）]。78例（43%）SS患者有既往或现在的溃疡，腿部溃疡与同侧下肢静脉功能不全之间存在高度显著的相关性（P
Chronic leg ulceration is a common cause of morbidity in Jamaican patients with homozygous sickle cell (SS) disease. Ulcers heal more rapidly on bed rest and deteriorate on prolonged standing, suggesting a role of venous hypertension in their persistence. This hypothesis has been tested by Doppler detection of venous competence in SS patients and in matched controls with a normal haemoglobin (AA) genotype in the Jamaican Cohort Study. Venous incompetence was significantly more frequent in SS disease [137/183 (75%)] than in non-pregnant AA controls [53/137 (39%)]. Past or present ulceration occurred in 78 (43%) SS patients, with a highly significant association between leg ulceration and venous incompetence in the same leg (P