TRANSPATH®:: an integrated database on signal transduction and a tool for array analysis
TRANSPATH®:: an integrated database on signal transduction and a tool for array analysis
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DOI：
10.1093/nar/gkg089
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Wingender, E
中科院分区：
文献类型：
--
作者：
Krull, M;Voss, N;Wingender, E
TRANSPATH（R）是一个关于基因调控网络的数据库系统，它将信号转导的植物信息与可视化和分析工具相结合。与TRANSFAC（R）（关于转录因子及其DNA结合位点的数据库）的整合提供了获得从配体到靶基因及其产物的完整信号传导途径的可能性，靶基因及其产物本身可能参与调节作用。截至2002年7月，TRANSPATH专业版3.2包含约9800个分子，>1800个基因和>11400个反应，这些反应收集自类似于5000个参考文献。利用ArrayAnalyzer（TM），已经开发了用于评估微阵列数据的集成工具。它使用TRANSPATH数据集来识别与相应阵列的上调或下调基因相关的通路中的关键调节因子。可以使用PathwayBuilder（TM）查看关键分子及其周围的网络，PathwayBuilder（TM）是一种提供四种不同可视化模式的工具。有关TRANSPATH的更多信息，请访问http://www.biobase.de/pages/products/databases.html。
TRANSPATH(R) is a database system about gene regulatory networks that combines encyclopedic information on signal transduction with tools for visualization and analysis. The integration with TRANSFAC(R), a database about transcription factors and their DNA binding sites, provides the possibility to obtain complete signaling pathways from ligand to target genes and their products, which may themselves be involved in regulatory action. As of July 2002, the TRANSPATH Professional release 3.2 contains about 9800 molecules, >1800 genes and >11400 reactions collected from similar to5000 references. With the ArrayAnalyzer(TM), an integrated tool has been developed for evaluation of microarray data. It uses the TRANSPATH data set to identify key regulators in pathways connected with up- or down-regulated genes of the respective array. The key molecules and their surrounding networks can be viewed with the PathwayBuilder(TM), a tool that offers four different modes of visualization. More information on TRANSPATH is available at http://www.biobase.de/pages/products/databases.html.