An integrated circuit readout for TOF-PET detectors for PET/MRI (Conference Presentation)
An integrated circuit readout for TOF-PET detectors for PET/MRI (Conference Presentation)
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用于 PET/MRI 的 TOF-PET 探测器的集成电路读数（会议演示）
DOI：
10.1117/12.2279439
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
C.S. Levin
中科院分区：
文献类型：
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作者：
I. Sacco;C.M. Chang;M. Ritzert;P. Fischer;C.S. Levin
用于组合 PET/磁共振成像 (MRI) 的新一代正电子发射断层扫描 (PET) 探测器必须实现极好的定时分辨率，同时还能够在高功率、动态电磁环境中同时采集数据。鉴于 SiPM 的高增益和快速响应及其对磁场的不敏感性，基于 SiPM 的探测器是该应用的自然选择。我们推出高度集成的读出电路“PETA”，专为 SiPM 读出和高性能 TOF-PET 所需的最佳时序分辨率而设计。 PETA 是一种凸块接合芯片，凸块之间的间距为 272 µm，适合紧凑型探测器设计。它包括 36 个读出通道，可用于单端和差分端前端。事件到达时间和能量通过 TDC/ADC 电路在芯片上进行测量和数字化。读出架构经过优化，可应对每个通道的高命中率。两个基于 PETA 读出的非常紧凑的 MR 兼容 TOF-PET 探测器模块已经构建并测试。每个都构建在单层（分别为陶瓷和 PCB 基板）上，在相对的表面上托管 SiPM 阵列和读出电子器件，并通过高效的集成冷却进行热解耦。重合测量显示，使用与匹配 SiPM 耦合的 2.25x2.25x10 mm3 LYSO 晶体阵列，重合时间分辨率为 230 ps FWHM。
The new generation positron emission tomography (PET) detectors for combined PET/magnetic resonance imaging (MRI) must achieve extremely good timing resolution while also being capable of simultaneous data acquisition in a high power, dynamic electromagnetic environment. SiPM-based detectors are a natural choice for this application, given the high gain and fast response of the SiPMs and their insensitivity to magnetic fields. We present the highly-integrated readout circuit “PETA”, specifically designed for SiPM readout and optimal timing resolution required for high performance TOF-PET. PETA is a bump-bonded chip, with pitch between bumps of 272 µm, suitable for compact detector design. It includes 36 readout channels, available with both single-ended and differential-ended front-ends. The event arrival time and energy are measured and digitized on chip with TDC/ADC circuits. The readout architecture is optimized for coping with high hit rate per channel. Two very compact MR-compatible TOF-PET detector modules based on PETA readout have been constructed and tested. Each is built on a single layer (ceramic and PCB substrate respectively), hosting the SiPM array and the readout electronics on opposite surfaces, and thermally decoupled with efficient integrated cooling. Coincidence measurements have shown coincidence time resolution of 230 ps FWHM using arrays of 2.25x2.25x10 mm3 LYSO crystals coupled to matching SiPMs.