Phase-sensitive X-ray imaging of synovial joints
Phase-sensitive X-ray imaging of synovial joints
复制标题
DOI：
10.1016/j.joca.2009.03.005
复制
发表时间：
2009-09-01
影响因子：
7
通讯作者：
Muehleman, C.
中科院分区：
文献类型：
--
作者：
Li, J.;Zhong, Z.;Muehleman, C.
目的：为了测试完整的滑膜关节，从而折射效应，沿着与传统的放射线照相术的衰减相敏X射线成像的功效，可以exploited.Design：完整的尸体人膝关节成像，在计算机断层扫描模式，使用基于分析仪的X射线，在国家同步加速器光源，布鲁克海文国家实验室的系统。用硅[1，1，1]反射双晶单色器制备了51keV X射线的准直扇形束。透射穿过样品的X射线束在垂直平面中衍射后借助于分析晶体成像，其中分析晶体被调谐到其半反射率点（6.5 μ rad）。一个二维的过滤反投影（FBP）算法被用于重建横向切片的images.Results：由此产生的图像表现出同时软组织和骨的对比度在一个水平，以前没有实现。可识别的结构，包括关节软骨，十字韧带，疏松结缔组织，crystalci，和chondrocalcinosis.Conclusion：相位敏感的X射线成像使用基于分析仪的系统呈现非常高质量的图像，软组织和硬组织内滑膜关节，具有高对比度和分辨率，从而为最终的临床应用前景。(C)2009年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To test the efficacy of phase-sensitive X-ray imaging for intact synovial joints, whereby refraction effects, along with the attenuation of conventional radiography, can be exploited.Design: Intact cadaveric human knee joints were imaged, in the computed tomographic mode, using an analyzer-based X-ray,system at the National Synchrotron Light Source, Brookhaven National Laboratory. A collimated fan beam of 51 keV X-rays was prepared by a silicon [1,1,1 reflection] double-crystal monochromator. The X-ray beam transmitted through the specimen was imaged after diffraction in the vertical plane by means of the analyzer crystal with the analyzer crystal tuned to its half-reflectivity point (6.5 mu rad). A two-dimensional filtered backprojection (FBP) algorithm was used for reconstructing transverse slices of images.Results: The resulting images demonstrate simultaneous soft tissue and bone contrast at a level that has not been achieved previously. Identifiable structures include articular cartilage, cruciate ligaments, loose connective tissue, menisci, and chondrocalcinosis.Conclusion: Phase-sensitive X-ray imaging using an analyzer-based system renders exceptionally high quality images of soft and hard tissues within synovial joints, with high contrast and resolution, and thus holds promise for the eventual clinical utility. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.