A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation
A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation
复制标题
DOI：
10.1016/j.neulet.2010.08.065
复制
发表时间：
2010-11-12
影响因子：
2.5
通讯作者：
Wakabayashi, Toshihiko
中科院分区：
文献类型：
--
作者：
Motomura, Kazuya;Ogura, Masatoshi;Wakabayashi, Toshihiko
已经阐明，脑放射治疗后的认知功能障碍可能与氧化应激诱导的海马神经发生损伤有关，海马神经发生损伤由增殖的神经干细胞或祖细胞介导。新型自由基清除剂依达拉奉（3-甲基-1-苯基-2-吡唑啉-5-酮）已在临床上用于减少缺血性卒中后的神经元损伤。以前，我们报道了自由基清除剂依达拉奉，这是目前用于治疗脑缺血患者，保护培养的人神经干细胞（NSC）辐射诱导的细胞死亡;观察到的保护作用更显着的NSC比脑肿瘤细胞。在此，我们在动物模型中证明依达拉奉可保护海马齿状回颗粒下区（SGZ）神经元免受辐射后的细胞死亡。此外，依达拉奉保护空间记忆保留缺陷，如Morris水迷宫测试所确定的。我们的研究可能揭示了自由基清除剂在颅脑放射治疗后受损神经发生中的有益作用。(C)2010爱思唯尔爱尔兰有限公司版权所有。
It has been elucidated that cognitive dysfunction following cranial radiotherapy might be linked to the oxidative stress-induced impairment of hippocampal neurogenesis that is mediated by proliferating neural stem or progenitor cells. The novel free-radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) has been clinically used to reduce neuronal damage following ischemic stroke. Previously, we reported that the free-radical scavenger, edaravone, which is currently used to treat patients with brain ischemia, protected cultured human neural stem cells (NSCs) from radiation-induced cell death; the protective effect was observed more significantly in NSCs than in brain tumor cells. Here, in animal models, we demonstrate that edaravone protects neurons in the subgranular zone (SGZ) of the dentate gyrus of the hippocampus from cell death after irradiation. Moreover, edaravone protected spatial memory retention deficits as determined by Morris water maze tests. Our study may shed some light on the beneficial effects of free-radical scavengers in impaired neurogenesis following cranial radiation therapy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.