Bacterial contamination of aerosol solutions containing antibiotics.
Bacterial contamination of aerosol solutions containing antibiotics.
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含有抗生素的气溶胶溶液的细菌污染。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
A. Kamiya
中科院分区：
文献类型：
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作者：
S. Oie;A. Kamiya
在对含有抗生素的气溶胶溶液（医院药物制剂，未添加防腐剂）的微生物污染调查中，多次使用7天后，六种残留溶液中有五种被污染，浓度为10(6)活菌计数/ml。污染物为葡萄糖不发酵的革兰氏阴性杆菌，如洋葱假单胞菌和脑膜炎败血症黄杆菌。在模拟的实际使用条件下，主要的污染物绿皮霉在气溶胶溶液中迅速繁殖。污染似乎是由于在室温下而不是在冰箱中储存多剂量溶液，以及经常重复使用注射器来测量这些溶液造成的。每次使用后立即冷藏，并在24小时内放弃注射器，消除了溶液的细菌污染。由于含有抗生素的气溶胶溶液本身就含有抗生素，因此没有对防止细菌污染给予足够的重视。因此，含有抗生素的气雾剂溶液应小心处理，以防止细菌污染。
In an investigation of microbial contamination of aerosol solutions containing antibiotics (hospital pharmaceutical preparations, no preservatives added), five of six residual solutions after multiple use for 7 days were contaminated at a concentration of 10(6) viable counts/ml. Contaminants were glucose-nonfermenting Gram-negative bacilli such as Pseudomonas cepacia and Flavobacterium meningosepticum. The major contaminant, P. cepacia, multiplied rapidly in the aerosol solution under simulated actual-use conditions. The contamination seemed to have been caused by storage, at room temperature instead of in a refrigerator, of the multiple-dose solutions and by frequent re-use of syringes to measure the solutions. Prompt refrigerator storage after each use of the solutions and abandonment of the syringes within 24 h eliminated bacterial contamination of the solutions. Sufficient attention is not paid to prevent bacterial contamination of aerosol solutions containing antibiotics because of the fact that they contain antibiotics. Thus aerosol solutions containing antibiotics should be handled with great care to prevent bacterial contamination.