STATHMIN PHOSPHORYLATION PATTERNS DISCRIMINATE BETWEEN DISTINCT TRANSDUCTION PATHWAYS OF HUMAN LYMPHOCYTE-T ACTIVATION THROUGH CD2 TRIGGERING
STATHMIN PHOSPHORYLATION PATTERNS DISCRIMINATE BETWEEN DISTINCT TRANSDUCTION PATHWAYS OF HUMAN LYMPHOCYTE-T ACTIVATION THROUGH CD2 TRIGGERING
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DOI：
10.1016/0014-5793(91)80020-4
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发表时间：
1991-08-05
期刊：
影响因子：
3.5
通讯作者：
SOBEL, A
中科院分区：
文献类型：
--
作者：
LEGOUVELLO, S;CHNEIWEISS, H;SOBEL, A
CD2触发人T淋巴细胞活化与不同相互作用蛋白激酶的活化有关，包括蛋白激酶C （PKC）。然而，其磷酸化底物的确切作用尚不清楚。我们在这里展示了pkc依赖性和非依赖性途径负责cd2诱导的安定素磷酸化，安定素是一种普遍存在的可溶性磷酸化蛋白，最有可能作为整合各种第二信使途径的一般细胞内中继。安定素的磷酸化变体提供了一个指纹，反映了第二信使途径的刺激。讨论了PKC和安定素在T淋巴细胞增殖调控中的作用。
CD2 triggering of human T lymphocyte activation has been associated with the activation of different interacting protein kinases, including protein kinase C (PKC). However the precise roles of its phosphorylated substrates are still unknown. We show here that PKC-dependent and -independent pathways are responsible for the CD2-induced phosphorylation of stathmin, a ubiquitous soluble phosphoprotein, most likely acting as a general intracellular relay integrating various second messenger pathways. The phosphorylated variants of stathmin provide a fingerprint reflecting the second messenger pathway(s) stimulated. The respective roles of both PKC and stathmin in the regulation of T lymphocyte proliferation are discussed.