Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients.
Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients.
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DOI：
10.1038/ki.2009.524
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发表时间：
2010-04
影响因子：
19.6
通讯作者：
Sarnak, Mark J.
中科院分区：
文献类型：
--
作者：
Huang, Cindy X.;Tighiouart, Hocine;Beddhu, Srinivasan;Cheung, Alfred K.;Dwyer, Johanna T.;Eknoyan, Garabed;Beck, Gerald J.;Levey, Andrew S.;Sarnak, Mark J.
体重指数越高，血液透析患者的预后越好；然而，这一指数并不区分脂肪和肌肉质量。为了阐明这一点，我们检查了血液透析研究中1709名患者的脂肪和肌肉质量指标与死亡率之间的关系。三头肌皮褶厚度用于评估体脂，臂中肌围用于评估肌肉质量。在调整了人口、心血管、透析和营养相关的危险因素后，使用Cox回归来评估身体成分测量与全因死亡率之间的关系。在中位数为2.5年的随访中，有802人死亡。在具有连续协变量的调整模型中，较高的三头肌皮褶厚度和较高的体重指数与降低死亡率风险显著相关，而较高的中臂肌围则显示出降低死亡率的趋势。在调整后的模型中，较低的四分位数的三头肌皮褶厚度、臂中肌围和体重指数都与较高的全因死亡率显著相关。这些研究表明，终末期肾病的身体成分与全因死亡率之间存在复杂的关系。
A higher body mass index is associated with better outcomes in hemodialysis patients; however, this index does not differentiate between fat and muscle mass. In order to clarify this, we examined the relationship between measures of fat and muscle mass and mortality in 1709 patients from the Hemodialysis Study. Triceps skin-fold thickness was used to assess body fat and mid-arm muscle circumference was used to assess muscle mass. Cox regression was used to evaluate the relationship between measures of body composition with all-cause mortality after adjustments for demographic, cardiovascular, dialysis, and nutrition-related risk factors. During a median follow-up of 2.5 years, there were 802 deaths. In adjusted models with continuous covariates, higher triceps skin-fold thickness and higher body mass index were significantly associated with decreased hazards of mortality, while higher mid-arm muscle circumference showed a trend toward decreased mortality. In adjusted models, lower quartiles of triceps skin-fold thickness, mid-arm muscle circumference, and body mass index were all significantly associated with higher all-cause mortality. These studies show that body composition in end-stage renal disease bears a complex relationship to all-cause mortality.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
影响因子：
19.6
作者：
Abbott, KC;Glanton, CW;Kimmel, PL
通讯作者：
Kimmel, PL
影响因子：
19.6
作者：
Kakiya, R.;Shoji, T.;Nishizawa, Y.
通讯作者：
Nishizawa, Y.
影响因子：
13.2
作者：
Elsayed, Essam F.;Tighiouart, Hocine;Sarnak, Mark J.
通讯作者：
Sarnak, Mark J.
影响因子：
3
作者：
GREENFIELD, S;APOLONE, G;CLEARY, PD
通讯作者：
CLEARY, PD