Right ventrolateral prefrontal cortex involvement in the integration of emotional processing: Parametric mediation analysis of fMRI
Right ventrolateral prefrontal cortex involvement in the integration of emotional processing: Parametric mediation analysis of fMRI
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DOI：
10.1016/j.neulet.2016.01.009
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发表时间：
2016-02-26
影响因子：
2.5
通讯作者：
Hoshi, Yoko
中科院分区：
文献类型：
--
作者：
Kida, Ikuhiro;Hoshi, Yoko
情绪在目标导向行为中起着重要的作用。虽然已经进行了大量的神经影像学研究，情绪产生和调节背后的神经机制仍然是难以捉摸的。除了情绪是一个复杂的过程这一事实之外，情绪反应的个体差异很大，这在一定程度上解释了这一点。目前的功能磁共振成像研究的目的是，首先指定的价依赖性的大脑激活，其次，澄清情感处理的区域之间的相互作用。我们测量了12名健康成年人在被动观看情感图片时的大脑激活。个体效价评分与额叶、顶叶、枕叶和皮质下区域（包括杏仁核）的激活呈负相关。对这些区域进行的参数中介分析表明，右腹外侧前额叶皮层（Brodmann区47）是与其他区域的效价评级的主要调解人。有趣的是，腹外侧前额叶皮层没有中介区。这些结果表明，右腹外侧前额叶皮层可能主要参与了视觉诱发情绪过程在效价维度上的整合。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Emotion plays an important role in goal-directed behavior. Although numerous neuroimaging studies have been conducted, the neural mechanisms behind emotion generation and regulation are still elusive. This is partly explained by large individual variations in emotional responses in addition to the fact that emotion is a complex process. The present functional magnetic resonance imaging study aimed firstly to specify valence-dependent brain activation, and secondly to clarify the interactions between the regions underlying emotional processing. We measured brain activation in 12 healthy adults while passively viewing affective pictures. The individual valence ratings were negatively correlated with activation in the frontal, parietal, occipital lobes, and in the subcortical regions including the amygdalae. The parametric mediation analysis performed on these regions showed that the right ventrolateral prefrontal cortex (Brodmann area 47) was main mediator of the valence ratings with other regions. Interestingly, there was no mediator region for the ventrolateral prefrontal cortex. These results indicated the possibility that the right ventrolateral prefrontal cortex mainly participated in the integration of visually induced emotional processes in the valence dimension. (C) 2016 Elsevier Ireland Ltd. All rights reserved.