Age and gender effects on bone mass density variation: finite elements simulation
Age and gender effects on bone mass density variation: finite elements simulation
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DOI：
10.1007/s10237-016-0834-x
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发表时间：
2017-04-01
影响因子：
3.5
通讯作者：
Hambli, Ridha
中科院分区：
文献类型：
--
作者：
Barkaoui, Abdelwahed;Ben Kahla, Rabeb;Hambli, Ridha
骨重塑是一种生理过程，通过该过程，骨不断地调整其结构以适应长期负荷的变化，这通过破骨细胞和成骨细胞之间的相互作用来体现。该过程可以通过对骨细胞分化和增殖的影响而受到许多局部因素的影响，骨细胞分化和增殖是由骨细胞产生并以旁分泌或自分泌方式起作用的。当前工作的目的是提供耦合细胞活动和机械行为的力学生物学有限元模型，以研究年龄和性别对骨重塑进化的影响。已对 2D 和 3D 人类股骨近端进行了一系列计算模拟。人们已经注意到与年龄和性别相关的骨小梁体积密度变化的影响，并讨论了造成这种现象的主要因素。
Bone remodeling is a physiological process by which bone constantly adapts its structure to changes in long-term loading manifested by interactions between osteoclasts and osteoblasts. This process can be influenced by many local factors, via effects on bone cells differentiation and proliferation, which are produced by bone cells and act in a paracrine or autocrine way. The aim of the current work is to provide mechanobiological finite elements modeling coupling both cellular activities and mechanical behavior in order to investigate age and gender effects on bone remodeling evolution. A series of computational simulations have been performed on a 2D and 3D human proximal femur. An age- and gender-related impacts on bulk density alteration of trabecular bone have been noticed, and the major actors responsible of this phenomenon have been then discussed.