Ambient temperature and biomarkers of heart failure: a repeated measures analysis.
Ambient temperature and biomarkers of heart failure: a repeated measures analysis.
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DOI：
10.1289/ehp.1104380
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发表时间：
2012-08
影响因子：
10.4
通讯作者：
Mittleman MA
中科院分区：
文献类型：
--
作者：
Wilker EH;Yeh G;Wellenius GA;Davis RB;Phillips RS;Mittleman MA
背景：极端温度与心力衰竭患者的住院和死亡有关，但很少有研究探讨其潜在机制。目的：在对稳定性心力衰竭患者进行的重复测量研究中，我们假设马萨诸塞州波士顿地区的室外温度（1 至 4 天移动平均值）与较高水平的炎症和肌细胞损伤生物标志物相关。方法：我们分析了一项已完成的临床试验的数据，该试验将 100 名患者随机分配到 12 周的太极拳课程或时间匹配的教育控制组。在基线、6周和12周时测量B型利钠肽（BNP）、C反应蛋白（CRP）和肿瘤坏死因子（TNF）。在基线和 12 周时测量内皮素-1。我们使用固定效应模型来评估与针对时变协变量进行调整的温度测量值的关联。结果：较高的表观温度与较高的 BNP 水平相关，从 2 天移动平均线开始，到 3 天和 4 天移动平均线达到统计显着性。 CRP 结果遵循类似的模式，但延迟了 1 天。表观温度的 3 天和 4 天移动平均值变化 5°C 与 11.3% 相关[95% 置信区间 (CI)：1.1、22.5； p = 0.03) 和 BNP 升高 11.4% (95% CI: 1.2, 22.5; p = 0.03)。表观温度 4 天移动平均值变化 5°C 与 CRP 升高 21.6%（95% CI：2.5, 44.2；p = 0.03）相关。没有观察到与 TNF 或内皮素-1 的明显关联。结论：在接受心力衰竭治疗的患者中，我们观察到温度与 BNP 和 CRP（心力衰竭预后和严重程度的预测因子）之间呈正相关。
Background: Extreme temperatures have been associated with hospitalization and death among individuals with heart failure, but few studies have explored the underlying mechanisms. Objectives: We hypothesized that outdoor temperature in the Boston, Massachusetts, area (1- to 4-day moving averages) would be associated with higher levels of biomarkers of inflammation and myocyte injury in a repeated-measures study of individuals with stable heart failure. Methods: We analyzed data from a completed clinical trial that randomized 100 patients to 12 weeks of tai chi classes or to time-matched education control. B-type natriuretic peptide (BNP), C-reactive protein (CRP), and tumor necrosis factor (TNF) were measured at baseline, 6 weeks, and 12 weeks. Endothelin-1 was measured at baseline and 12 weeks. We used fixed effects models to evaluate associations with measures of temperature that were adjusted for time-varying covariates. Results: Higher apparent temperature was associated with higher levels of BNP beginning with 2-day moving averages and reached statistical significance for 3- and 4-day moving averages. CRP results followed a similar pattern but were delayed by 1 day. A 5°C change in 3- and 4-day moving averages of apparent temperature was associated with 11.3% [95% confidence interval (CI): 1.1, 22.5; p = 0.03) and 11.4% (95% CI: 1.2, 22.5; p = 0.03) higher BNP. A 5°C change in the 4-day moving average of apparent temperature was associated with 21.6% (95% CI: 2.5, 44.2; p = 0.03) higher CRP. No clear associations with TNF or endothelin-1 were observed. Conclusions: Among patients undergoing treatment for heart failure, we observed positive associations between temperature and both BNP and CRP—predictors of heart failure prognosis and severity.
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肿瘤坏死因子-α 和心力衰竭死亡率：一项社区研究。
影响因子：
37.8
作者：
Dunlay SM;Weston SA;Redfield MM;Killian JM;Roger VL
通讯作者：
Roger VL
影响因子：
5.4
作者：
Basu, Rupa;Feng, Wen-Ying;Ostro, Bart D.
通讯作者：
Ostro, Bart D.
DOI：
10.1186/1476-069x-9-42
发表时间：
2010-07-23
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Halonen JI;Zanobetti A;Sparrow D;Vokonas PS;Schwartz J
通讯作者：
Schwartz J
影响因子：
37.8
作者：
Bolger, AP;Sharma, R;Gatzoulis, MA
通讯作者：
Gatzoulis, MA
影响因子：
37.8
作者：
Cui, J;Arbab-Zadeh, A;Crandall, CG
通讯作者：
Crandall, CG