Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study

Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study
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DOI：
10.1016/j.alcohol.2003.06.001
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发表时间：
2003-07-01
期刊：
ALCOHOL
影响因子：
2.3
通讯作者：
Ehlers, CL
Ehlers, CL
中科院分区：
医学4区
文献类型：
--
作者：
Dahl, RE;Williamson, DE;Ehlers, CL

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本研究旨在探讨酒精使用障碍家族史对抑郁症青年样本的频谱脑电图（EEG）睡眠测量的影响。我们评估了32名有和没有酒精使用障碍家族史的抑郁青年（8-16岁）的睡眠。18名参与者（10名男性和8名女性）报告了酒精使用障碍的阳性父亲史，并组成了家族史阳性（FHP）组。功率谱分析显示，在第一和第二非快速眼动（REM）期，第二REM期，夜间清醒和整个夜间，FHP组的男孩在7.50-11.00 Hz波段（慢α）的功率增加。结果还显示，在非REM、REM和清醒期，较高的α频率（11.00-12.25 Hz）的功率增加。在FHP组的男孩中，在第二REM期的δ频率（0.75-4.50 Hz）中也观察到频谱功率的显著增加。这些发现与以前的研究结果一致，表明EEG α功率与酒精使用障碍家族史呈正相关。(C)2003年爱思唯尔公司All rights reserved.
The current study was designed to examine the effects of family history of alcohol use disorders on spectral electroencephalographic (EEG) sleep measures obtained in a sample of youth with depression. We evaluated sleep in 32 depressed youth (8-16 years of age) with and without a family history of alcohol use disorders. Eighteen of the participants (10 males and 8 females) reported a positive paternal history of alcohol use disorders and made up the family history positive (FHP) group. Power-spectral analyses revealed that increased power in the 7.50-11.00 Hz band (slow alpha) was associated with boys in the FHP group for the first and second non-rapid eye movement (REM) periods, second REM period, awake during the night, and entire night period. Results also showed increased power in the higher alpha frequencies (11.00-12.25 Hz) for non-REM, REM, and awake periods. A significant increase in spectral power was also observed in boys in the FHP group in the delta frequencies (0.75-4.50 Hz) during the second REM period. These findings are consistent with results from previous studies, demonstrating that EEG alpha power is positively associated with a family history of alcohol use disorders. (C) 2003 Elsevier Inc. All rights reserved.