Calcium signaling in cardiac mitochondria.
Calcium signaling in cardiac mitochondria.
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DOI：
10.1016/j.yjmcc.2012.12.021
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发表时间：
2013-05
影响因子：
5
通讯作者：
Blatter LA
中科院分区：
文献类型：
--
作者：
Dedkova EN;Blatter LA
线粒体钙信号参与细胞能量代谢的调节，线粒体通过储存钙离子、整形细胞内钙信号和产生收缩所需的三磷酸腺苷参与心肌兴奋收缩偶联(ECC)。线粒体内膜具有一套复杂的钙摄取和排出通道和转运体系统，可以解码胞浆钙信号，并将钙储存在线粒体基质中。然而，存在争议的是，心脏跳动中ECC下的快速胞浆钙瞬变是迅速传递到基质间隔室，还是被线粒体钙转运机制缓慢整合。本文综述了心肌线粒体钙转运和缓冲方面已有的和新的发现，并讨论了支持或反对线粒体在体外循环过程中迅速摄取钙的证据。
Mitochondrial Ca signaling contributes to the regulation of cellular energy metabolism, and mitochondria participate in cardiac excitation-contraction coupling (ECC) through their ability to store Ca, shape the cytosolic Ca signals and generate ATP required for contraction. The mitochondrial inner membrane is equipped with an elaborate system of channels and transporters for Ca uptake and extrusion that allows for the decoding of cytosolic Ca signals, and the storage of Ca in the mitochondrial matrix compartment. Controversy, however remains whether the fast cytosolic Ca transients underlying ECC in the beating heart are transmitted rapidly into the matrix compartment or slowly integrated by the mitochondrial Ca transport machinery. This review summarizes established and novel findings on cardiac mitochondrial Ca transport and buffering, and discusses the evidence either supporting or arguing against the idea that Ca can be taken up rapidly by mitochondria during ECC.
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影响因子：
20.1
作者：
Chen Y;Csordás G;Jowdy C;Schneider TG;Csordás N;Wang W;Liu Y;Kohlhaas M;Meiser M;Bergem S;Nerbonne JM;Dorn GW 2nd;Maack C
通讯作者：
Maack C
影响因子：
4.8
作者：
Chalmers, S;Nicholls, DG
通讯作者：
Nicholls, DG
影响因子：
3
作者：
BERNARDI, P;BROEKEMEIER, KM;PFEIFFER, DR
通讯作者：
PFEIFFER, DR
影响因子：
20.1
作者：
BLATTER, LA;MCGUIGAN, JAS
通讯作者：
MCGUIGAN, JAS
影响因子：
64.8
作者：
Baines, CP;Kaiser, RA;Molkentin, JD
通讯作者：
Molkentin, JD