Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex
Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex
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DOI：
10.1016/s0367-326x(00)00225-2
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发表时间：
2000-12-01
期刊：
影响因子：
3.4
通讯作者：
Sharma, OP
中科院分区：
文献类型：
--
作者：
Bani, S;Kaul, A;Sharma, OP
以50-200 mg/kg的剂量灌胃给予狼毒乳胶的水溶性部分（AER），在大鼠和小鼠的不同急性和慢性试验模型中显示出剂量依赖性的抗炎和抗关节炎作用。对棉球肉芽肿形成的抑制作用不明显，但溃疡评分较低。大鼠和小鼠经口LD 50均大于1500 mg/kg。(C)2000 Elsevier Science B. V.保留所有权利。
The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD50 was more than 1500 mg/kg in both rats and mice. (C) 2000 Elsevier Science B.V. All rights reserved.