Reticular erythematous mucinosis: light and electron microscopy, irnmunofluorescence and histochemical findings
Reticular erythematous mucinosis: light and electron microscopy, irnmunofluorescence and histochemical findings
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网状红斑性粘蛋白沉积症：光学和电子显微镜、免疫荧光和组织化学检查结果
DOI：
10.1111/j.1365-2133.1982.tb00896.x
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发表时间：
1982
影响因子：
10.3
通讯作者：
R. Church
中科院分区：
文献类型：
--
作者：
S. Bleehen;D. Slater;J. Mahood;R. Church
对5例网状红斑性粘蛋白沉着症患者进行了皮肤活检和光敏试验。光镜下可见真皮单个核细胞浸润(主要由淋巴细胞组成)，胶原束脱落，弹力纤维断裂。组织化学染色显示真皮粘蛋白增多，其轮廓与透明质酸一致。其中1例用胶体铁染色、电子显微镜和X射线显微分析显示粘蛋白的超微结构分布。2例真皮绒毛细胞和周细胞胞浆内可见病毒样的管状聚集体。免疫球蛋白、纤维蛋白和补体免疫荧光染色均为阴性。
Five patients with reticular erythematous mucinosis were studied by skin biopsy and phototesting. Light microscopy showed a dermal mononuclear cell infiltrate (composed largely of lymphocytes), separation of collagen bundles and fragmentation of elastic fibres. Histochemical stains showed increased dermal mucin with a profile consistent with hyaluronic acid. In one case, the ultrastructural distribution of mucin was demonstrated using colloidal iron staining, electron microscopy and X‐ray microanalysis. In two cases, virus‐like tubular aggregates were identified in the cytoplasm of dermal cndothclial cells and pericytes. Immunofluorescent staining for immunoglobulins, fibrin and complement was negative.