Current approaches in treatment of triple-negative breast cancer.
Current approaches in treatment of triple-negative breast cancer.
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DOI:
10.7497/j.issn.2095-3941.2015.0030
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发表时间:
2015-06
影响因子:
5.5
通讯作者:
El-Hadaad HA
中科院分区:
文献类型:
--
作者:
Wahba HA;El-Hadaad HA
Triple-negative breast cancer (TNBC) is diagnosed more frequently in younger and premenopausal women and is highly prevalent in African American women. TNBC is a term derived from tumors that are characterized by the absence of ER, PgR, and HER2. So patients with TNBC do not benefit from hormonal or trastuzumab-based therapies. TNBCs are biologically aggressive, although some reports suggest that they respond to chemotherapy better than other types of breast cancer, prognosis remains poor. This is due to: shortened disease-free interval in the adjuvant and neoadjuvant setting and a more aggressive course in the metastatic setting.
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