Current approaches in treatment of triple-negative breast cancer.

Current approaches in treatment of triple-negative breast cancer.
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DOI:
10.7497/j.issn.2095-3941.2015.0030
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发表时间:
2015-06
影响因子:
5.5
通讯作者:
El-Hadaad HA
El-Hadaad HA
中科院分区:
医学2区
文献类型:
--
作者:
Wahba HA;El-Hadaad HA

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三阴性乳腺癌(TNBC)在年轻和绝经前妇女中更常见,在非裔美国妇女中非常普遍。TNBC是一个源于肿瘤的术语,其特征是缺乏ER、PgR和HER2。因此,TNBC患者不能从激素或曲妥珠单抗治疗中获益。tnbc具有生物侵袭性,尽管一些报道表明它们对化疗的反应比其他类型的乳腺癌更好,但预后仍然很差。这是由于:在辅助和新辅助设置缩短无病间隔和转移设置更积极的过程。
Triple-negative breast cancer (TNBC) is diagnosed more frequently in younger and premenopausal women and is highly prevalent in African American women. TNBC is a term derived from tumors that are characterized by the absence of ER, PgR, and HER2. So patients with TNBC do not benefit from hormonal or trastuzumab-based therapies. TNBCs are biologically aggressive, although some reports suggest that they respond to chemotherapy better than other types of breast cancer, prognosis remains poor. This is due to: shortened disease-free interval in the adjuvant and neoadjuvant setting and a more aggressive course in the metastatic setting.
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