Research Progress of circRNAs in Inflammatory Mechanisms of Diabetic Retinopathy: An Emerging Star with Potential Therapeutic Targets
Research Progress of circRNAs in Inflammatory Mechanisms of Diabetic Retinopathy: An Emerging Star with Potential Therapeutic Targets
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DOI：
10.1080/02713683.2021.1995002
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发表时间：
2021-12
影响因子：
2
通讯作者：
Shuai He;Chufeng Gu;Tong Su;Qinghua Qiu
中科院分区：
文献类型：
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作者：
Shuai He;Chufeng Gu;Tong Su;Qinghua Qiu
摘要目的：我们总结了现有的研究，阐述了circRNA的生物起源和功能，以及circRNA异常表达在炎症和糖尿病视网膜病变（DR）机制中的作用，并进一步探讨了circRNA在DR炎症中的重要作用。方法：我们对截至2021年8月的大量电子数据库（PubMed，GeneMedical和MEDLINE）进行了系统的文献检索。结果如下：本文综述了circRNA的生物学起源和功能，并重点介绍了与DR相关的炎症介质的组成成分，包括circHIPK 3、circZNF 609、circRNA_0084043、circ_0002570、circ_0041795、circEhmt 1和circ-ITCH等。此外，我们不仅提出了circRNA的表观遗传学功能，还提出了炎症反应的新形式，包括焦亡，以激发该领域的进一步探索和创造性研究。结论：CircRNA通过异常表达和基因表达调控参与DR炎症的进展和发展，是一个具有潜在治疗靶点的新兴星星。
ABSTRACT Purpose: We summarized the existing studies to elaborate the biogenesis and function of circRNAs, the effect of aberrant circRNAs expression in the mechanism of inflammation and diabetic retinopathy (DR) respectively and further explored the vital roles of circRNAs in inflammation involved in DR. Methods: We conducted a systematical literature search of abundant electronic databases (PubMed, GeneMedical and MEDLINE) up to August 2021. Results: In this review, we exhibited the biogenesis and function of circRNAs and highlighted the components of inflammatory mediators implicated in DR. Numerous circRNAs, such as circHIPK3, circZNF609, circRNA_0084043, circ_0002570, circ_0041795, circEhmt1 and circ-ITCH were discovered to play vital roles in inflammation involved in DR, which provided new ideas for diagnosis and treatment of DR. Moreover, we proposed not only the epigenetic functions of circRNAs but also novel forms of the inflammatory response, including pyroptosis, to inspire further exploration and creative research in this field. Conclusion: CircRNAs were implicated in the progression and development of inflammation in DR via aberrant expression and modulation of gene expression, serving as an emerging star with potential therapeutic targets.