Total synthesis and absolute stereochemistry of plakortone E
Total synthesis and absolute stereochemistry of plakortone E
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DOI：
10.1016/j.tetlet.2006.02.025
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发表时间：
2006-04-03
影响因子：
1.8
通讯作者：
Ohira, S
中科院分区：
文献类型：
--
作者：
Akiyama, M;Isoda, Y;Ohira, S
通过合成外消旋C-8同分异构体(+/-)-2和(-)-1本身，确定了加勒比海绵的细胞毒性代谢物Plakorone E的绝对立体化学为1，与天然化合物相同。(C)2006爱思唯尔有限公司。保留所有权利。
The absolute stereochemistry of plakortone E, it cytotoxic metabolite of the Caribbean sponge, was established to be 1. by the synthesis of the racemic C-8 epimer (+/-)-2 and then of (-)-1 itself, which was identical with the natural compound. (c) 2006 Elsevier Ltd. All rights reserved.