Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice
Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice
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DOI：
10.1097/00001756-199902050-00015
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发表时间：
1999-02-05
期刊：
影响因子：
1.7
通讯作者：
Kelley, KW
中科院分区：
文献类型：
--
作者：
Dantzer, R;Gheusi, G;Kelley, KW
为了评估胰岛素样生长因子-1（IGF-1）对促炎细胞因子脑效应的可能调节作用，将行为抑制剂量（100 ng）的细胞因子诱导剂脂多糖（LPS）注射到雄性CD-1小鼠的侧脑室中，并观察它们对不同剂量的IGF-1的反应在处理前和处理后的不同时间间隔进行的行为测试期间，测量浓度（0、100和1000 ng）。LPS诱导了一种深刻的行为抑郁症，这种抑郁症被测试的更高剂量的IGF-1所消除。由于LPS的行为效应是由促炎细胞因子的局部合成和结果介导的，因此这些结果表明IGF-1干扰脑中促炎细胞因子的产生和/或作用。(C)1999年利平科特威廉姆斯&威尔金斯。
To assess the possible modulatory effects of insulin-like growth factor-1 (IGF-1) on the brain effects of proinflammatory cytokines, male CD-1 mice were injected into the lateral ventricle of the brain with a behaviorally depressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured during behavioral tests carried before and at various time intervals after treatment. LPS induced a profound behavioral depression that was abrogated by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are mediated by the local synthesis and results of proinflammatory cytokines, these results indicate that IGF-1 interferes with the production and/or action of proinflammatory cytokines in the brain. (C) 1999 Lippincott Williams & Wilkins.