Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage
Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage
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DOI：
10.1016/j.regpep.2004.02.010
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发表时间：
2004-08-15
影响因子：
--
通讯作者：
Hahn, EG
中科院分区：
文献类型：
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作者：
Brzozowski, T;Konturek, PC;Hahn, EG
Ghrelin是一种存在于胃粘膜中的蛋白质，它参与调节食物摄入和生长激素（GH）的释放，但其对胃分泌和粘膜完整性的影响尚不清楚。观察Ghrelin对75%乙醇和3.5h水浸束缚应激大鼠胃分泌、血浆胃泌素及胃粘膜损伤的影响。外源性生长激素释放肽（5、10、20、40和80 μ g/kg i. p.）增加胃酸分泌，减轻乙醇和WRS引起的胃损伤，并伴有血浆ghrelin水平、胃粘膜血流量（GBF）和管腔NO浓度的显著升高。Ghrelin诱导的保护作用可被迷走神经切断所消除，并可被考克斯抑制、神经毒性剂量的辣椒素或CGRP（8-37）使传入神经失活以及L-NNA抑制NOS所减弱，但不受延髓切除术和给予6-羟基多巴胺的影响。我们的结论是，ghrelin发挥了强大的保护作用，对大鼠的胃暴露于乙醇和WRS，这些影响依赖于迷走神经活动，感觉神经和充血介导的NOS-NO和COX-PG系统。(C)2004 Elsevier B.V保留所有权利。
Ghrelin, identified in the gastric mucosa has been involved in control of food intake and growth hormone (GH) release but little is known about its influence on gastric secretion and mucosal integrity. The effects of ghrelin on gastric secretion, plasma gastrin and gastric lesions induced in rats by 75% ethanol or 3.5 h of water immersion and restraint stress (WRS) were determined. Exogenous ghrelin (5, 10, 20, 40 and 80 mug/kg i.p.) increased gastric acid secretion and attenuated gastric lesions induced by ethanol and WRS and this was accompanied by the significant rise in plasma ghrelin level, gastric mucosal blood flow (GBF) and luminal NO concentrations. Ghrelin-induced protection was abolished by vagotomy and attenuated by suppression of COX, deactivation of afferent nerves with neurotoxic dose of capsaicin or CGRP(8-37) and by inhibition of NOS with L-NNA but not influenced by medullectomy and administration of 6-hydroxydopamine. We conclude that ghrelin exerts a potent protective action on the stomach of rats exposed to ethanol and WRS, and these effects depend upon vagal activity, sensory nerves and hyperemia mediated by NOS-NO and COX-PG systems. (C) 2004 Elsevier B.V All rights reserved.