The relationship between Interleukin-27 gene polymorphisms kawasaki disease in a population of Chinese children
The relationship between Interleukin-27 gene polymorphisms kawasaki disease in a population of Chinese children
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中国儿童人群白细胞介素27基因多态性与川崎病的关系
DOI：
10.1017/s1047951118000914
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发表时间：
2018
影响因子：
1
通讯作者：
Yi Qijian
中科院分区：
文献类型：
--
作者：
Si Feifei;Wu Yao;Wang Xianmin;Gao Fang;Yang Dan;Liu Ruixi;Yi Qijian
背景川崎病是发达国家儿童获得性心脏病的主要原因。白细胞介素-6/白细胞介素-12细胞因子家族有许多成员，包括矛盾的抗炎和促炎白细胞介素-27。最近的研究表明，白细胞介素-27在免疫疾病中起作用。鉴于此，我们试图评估白介素-27遗传多态性与中国儿童川崎病之间的关系。方法与结果对100例川崎病患儿和98例健康儿童（对照）进行白介素-27基因分型，直接测序得到8个单核苷酸多态性：rs17855750、rs40837、rs26528、rs428253、rs4740、rs4905、rs153109和rs181206。川崎病患者白细胞介素-27基因型与对照组无显著差异。在8个单核苷酸多态性中，rs17855750 （T>G）、rs40837 （a >G）、rs4740 （G> a）、rs4905 （a >G）、rs153109 （T>C）和rs26528 （a >G）单核苷酸多态性的儿童发生川崎病合并冠状动脉病变的风险显著增加。rs17855750 （T>G）尤其如此，该基因在川崎病合并冠状动脉动脉瘤患儿中出现的频率更高。结论这些发现可作为评估儿童发生川崎病可能性的危险因素，并为今后川崎病的治疗制定提供依据。
BackgroundKawasaki disease is the leading cause of acquired heart disease in children from developed countries. The Interleukin-6/ Interleukin-12 cytokine family has many members, including the paradoxical anti- and pro-inflammatory Interleukin-27. Recent studies have demonstrated that Interleukin-27 plays a role in immune diseases. Given this, we sought to evaluate the association between Interleukin-27 genetic polymorphisms and Kawasaki disease in Chinese children.Methods and resultsInterleukin-27 was genotyped in 100 Kawasaki disease children and 98 healthy children (controls), resulting in the direct sequencing of eight Single-nucleotide Polymorphisms: rs17855750, rs40837, rs26528, rs428253, rs4740, rs4905, rs153109, and rs181206). There were no significant differences in Interleukin-27 genotypes between Kawasaki disease and control groups. Of the eight Single-nucleotide Polymorphisms, there was a significant increase in the risk of Kawasaki disease with coronary arterial lesions in children with the rs17855750 (T>G), rs40837 (A>G), rs4740 (G>A), rs4905 (A>G), rs153109 (T>C), and rs26528 (A>G) Single-nucleotide Polymorphisms. This was particularly true for rs17855750 (T>G), which had a greater frequency in Kawasaki disease children with coronary arterial aneurysm.ConclusionThese findings may be used as risk factors when assessing a child’s likelihood of developing Kawasaki disease, as well as for the development of future therapeutic treatments for Kawasaki disease.