The oxygen affinity of sickle hemoglobin
The oxygen affinity of sickle hemoglobin
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DOI：
10.1016/j.resp.2007.12.005
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发表时间：
2008-03-20
影响因子：
2.3
通讯作者：
Aldrich, Thomas K.
中科院分区：
文献类型：
--
作者：
Abdu, Amgad;Gomez-Marquez, Jose;Aldrich, Thomas K.
镰状细胞病（SCD）的氧合血红蛋白解离曲线右移被认为会导致异常低的动脉血氧饱和度（S-o2），即使氧分压（P-o2）正常。然而，没有聚合物形成（在常氧条件下最小），HbS氧亲和力是正常的。我们假设在SCD中，当P-o2正常时，体内S-o2正常。我们回顾性检查了50个血气和二氧化碳血氧测定样本SCD患者和对照匹配的pH值，PO 2，和碳氧血红蛋白。对照数据接近Severinghaus曲线，非低氧血症（S-O2 > 92.5%）SCD数据也是如此。相比之下，低氧血症（S-o2 < 92.5%）SCD数据远低于标准曲线。因此，尽管SCD患者的氧亲和力在缺氧条件下是低的，但在正常动脉SO下是正常的。因此，异常低饱和度的发现表明P-O2异常低。鉴于我们之前的发现，脉搏血氧仪忠实地反映了SCD中的饱和度，SCD中的低脉搏血氧仪读数构成了气体交换受损的可靠证据。(C)2007 Elsevier B. V.保留所有权利。
The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (S-o2), even when oxygen partial pressure (P-o2) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in Vivo S-o2 is normal when P-o2 is normal. We retrospectively examined 50 blood gas and COoximetry samples from SCD patients and from controls matched for pH, Po2, and carboxyhemoglobin. Control data fell close to the Severinghaus curve, as did non-hypoxemic (S-O2 > 92.5%) SCD data. In contrast, hypoxemic (S-o2 < 92.5%) SCD data fell well below the standard curve. Thus, although SCD patients' oxygen affinity is low under hypoxic conditions, it is normal at normal arterial So, Therefore, a finding of abnormally low saturation demonstrates that P-o2 is abnormally low. Given our previous finding that pulse oximetry faithfully reflects saturation in SCD, low pulse oximeter readings in SCD constitute reliable evidence of impaired gas exchange. (C) 2007 Elsevier B.V. All rights reserved.