Atrial receptor modulation of renal nerve activity in the nonhuman primate.
Atrial receptor modulation of renal nerve activity in the nonhuman primate.
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非人灵长类动物肾神经活动的心房受体调节。
DOI：
10.1152/ajprenal.1982.242.6.f592
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Zucker,IH
中科院分区：
文献类型：
--
作者：
Gilmore,JP;Echtenkamp,S;Wesley,CR;Zucker,IH
在非人类灵长类食蟹猴中进行了实验，以确定低压受体调节肾神经活动 (RNA) 的程度。左心房压力（LAP）通过左心房气球充气或血管内容量扩张而增加。服用肾上腺素会增加动脉压（AP）。当所有反射都完好无损时，气球膨胀会导致 RNA 发生不同的变化。在双侧迷走神经切断的动物中，球囊充气显着增加了 RNA。与完整状态相比，无论是颈动脉窦去神经还是窦主动脉去神经，在球囊膨胀过程中对RNA均没有显着影响。然而，压力感受器去神经组的反应明显低于迷走神经切断组。迷走神经切断术加上窦主动脉去神经术基本上防止了球囊膨胀对 RNA 的任何影响。每次 AP 增加时，体积扩张对 RNA 的抑制作用比肾上腺素更大。然而，双侧颈部迷走神经切断术后，这种差异被消除。这些实验证明低压和高压受体对非人灵长类动物的 RNA 具有显着影响和相互作用。
Experiments were done in the nonhuman primate Macaca fascicularis to determine the extent to which low-pressure receptors modulate renal nerve activity (RNA). Left atrial pressure (LAP) was increased either by inflating a balloon in the left atrium or by intravascular volume expansion. Arterial pressure (AP) was increased by the administration of epinephrine. Balloon inflation produced variable changes in RNA when all reflexes were intact. In the bilateral vagotomized animal, balloon inflation significantly increased RNA. Compared with the intact state, neither carotid sinus denervation nor sinoaortic denervation had a significant influence on RNA during balloon inflation. The response of both baroreceptor-denervated groups, however, was significantly less than that of the vagotomized group. Vagotomy plus sinoaortic denervation essentially prevented any effect of balloon inflation on RNA. Volume expansion produced a greater inhibition of RNA per increase in AP than did epinephrine. However, this difference was abolished after bilateral cervical vagotomy. These experiments demonstrate a significant influence and interplay of low- and high-pressure receptors on RNA in the nonhuman primate.