Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients.
Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients.
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非糖尿病腹膜透析患者血清鸢尾素水平与腹膜透析充分性相关
DOI：
10.1371/journal.pone.0176137
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Peng H
中科院分区：
文献类型：
--
作者：
Tan Z;Ye Z;Zhang J;Chen Y;Cheng C;Wang C;Liu X;Lou T;Peng H
背景鸢尾素是最近发现的一种肌因子，被认为与大多数透析患者的多种代谢异常有关。然而，肌因子在腹膜透析中的作用尚未得到深入研究。本研究旨在评估腹膜透析患者血清鸢尾素水平，并建立其与透析充分性、胰岛素抵抗和骨代谢状态的关系。方法收集59例非糖尿病腹膜透析患者和52例年龄、性别匹配的健康对照者。采用酶联免疫吸附法测定血清中鸢尾素浓度。研究了血清鸢尾素与透析充分性、临床和代谢变量之间的相关性。结果非糖尿病腹膜透析患者血清鸢尾素水平（17.02ng/ml）明显低于健康对照组（22.17ng/ml）（P<0.001）。多因素回归分析显示，腹膜透析患者空腹血糖水平与血清鸢尾素水平呈负相关。在我们的患者中，血清鸢尾素水平与胰岛素抵抗和骨代谢无关。在腹膜透析患者中，血清鸢尾素水平与腹膜Kt/Vurea（β = 4.933，95%CI = 0.536-9.331，P = 0.029）和腹膜CCr（β = 0.259，95%CI = 0.053-0.465，P = 0.015）呈正相关。结论非糖尿病腹膜透析患者血清鸢尾素水平较低，且与腹膜透析充分性相关，充分透析可促进鸢尾素分泌。需要进一步的研究来证实。
Background Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. Methods A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated. Results Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/Vurea (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal CCr (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients. Conclusions The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation.