AN IMMUNO-CYTOCHEMICAL STUDY OF ALPHA-LACTALBUMIN IN HUMAN-BREAST TISSUE
AN IMMUNO-CYTOCHEMICAL STUDY OF ALPHA-LACTALBUMIN IN HUMAN-BREAST TISSUE
复制标题
DOI：
10.1002/path.1711370103
复制
发表时间：
1982-01-01
影响因子：
7.3
通讯作者：
ORMEROD, MG
中科院分区：
文献类型：
--
作者：
BAILEY, AJ;SLOANE, JP;ORMEROD, MG
本文用间接免疫过氧化物酶技术，在福尔马林固定石蜡包埋切片上，研究了乳蛋白在人乳腺组织中的分布。在检查的所有哺乳期乳房和妊娠18周以上受试者的所有乳房中均发现了该蛋白。也见于一小部分非妊娠、非哺乳期患者，通常局限于小的局灶性分泌小叶病变（称为哺乳病灶），但偶尔也见于形态正常的小叶。既往妊娠似乎不是乳清蛋白分泌的先决条件，本研究表明可能与激素制剂的使用有关。研究了各种各样的良性和恶性乳腺病变，除了妊娠或哺乳期病灶的纤维腺瘤外，没有发现含有该蛋白。从所有44例乳腺癌研究的乳白蛋白的情况下，它没有发挥作用，作为一个标志物，在组织病理学诊断或临床监测这种疾病。
The distribution of the milk protein, lactalbumin, was studied in human breast tissue by the indirect immunoperoxidase technique on formalin fixed paraffin embedded sections. It was found in all lactating breasts examined and in all breasts from subjects who were more than 18 wk pregnant. It was also seen in a small proportion of non-pregnant, non-lactating patients usually confined to small focal secretory lobular lesions known as lactational foci but also occasionally in morphologically normal lobules. Previous pregnancy does not appear to be a pre-requisite for lactalbumin secretion and this study suggests a possible relationship with usage of hormonal preparations. A wide variety of benign and malignant breast lesions were studied and none was found to contain the protein, except for fibroadenomas from patients who were pregnant or who harbored lactational foci. The absence of lactalbumin from all the 44 breast carcinomas studied suggests that it has no role to play as a marker in the histopathological diagnosis or clinical monitoring of this disease.