Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease.
Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease.
复制标题
衰老加速小鼠颞下颌关节的年龄相关变化。
DOI：
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发表时间：
1989
影响因子：
6
通讯作者：
T. Takeda
中科院分区：
文献类型：
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作者：
W. H. Chen;M. Hosokawa;T. Tsuboyama;T. Ono;T. Iizuka;T. Takeda
本实验观察了快速老化小鼠（SAM）颞下颌关节（TMJ）髁突的形态学变化。随着年龄的增长，所有的SAM菌株都表现出退行性关节疾病，这些退行性关节疾病是由髁突表面的退行性变化引起的，例如，粗糙、裂隙和侵蚀。这些退行性变化与可导致髁突变形的主动重塑一致。此外，短寿命的SAM-P（加速衰老倾向小鼠）品系比SAM-R（加速衰老抗性小鼠）品系更早地发生这些退行性变化。因此，SAM中退行性关节疾病的发展不仅与实际年龄密切相关，而且与加速衰老现象密切相关。在SAM-P系列中，SAM-P/3品系最先表现出退行性变化（7 - 9月龄约50%，12月龄以上100%），此后表现出严重变化伴明显畸形的发生率最高。作为退行性关节疾病的模型，这种SAM菌株应该是有用的。
Age-related changes of the condyle of the temporomandibular joint (TMJ) in strains of Senescence Accelerated Mouse (SAM) were investigated. With advancing age, all strains of SAM showed degenerative joint disease initiated by degenerative changes such as eg, roughness, fissure, and erosion on the condylar surface. These degenerative changes were in concert with an active remodeling that can lead to deformation of the condyle. Moreover, the short-lived SAM-P (accelerated senescence prone mouse) strains developed these degenerative changes earlier than did the SAM-R (accelerated senescence resistant mouse) strains. Thus, development of degenerative joint disease in SAM was closely related not only to chronological age but also to the accelerated senescence phenomenon. Of the SAM-P series, the SAM-P/3 strain was the first to manifest degenerative changes (approximately 50% at 7 to 9 months of age and 100% over 12 months of age) and thereafter showed the highest incidence of severe changes with overt deformity. As a model of degenerative joint disease, this strain of SAM should prove useful.