VEGF and Notch Signaling The Yin and Yang of Angiogenic Sprouting
VEGF and Notch Signaling The Yin and Yang of Angiogenic Sprouting
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DOI：
10.4161/cam.1.3.4978
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发表时间：
2007-07-01
影响因子：
3.2
通讯作者：
Gerhardt, Holger
中科院分区：
文献类型：
--
作者：
Hellstrom, Mats;Phng, Li-Kun;Gerhardt, Holger
血管生成中的管状芽依赖于引导和引导芽的内皮尖端细胞与其邻近的茎细胞之间的分工，后者分裂并形成血管腔。我们之前了解了肝素结合血管内皮生长因子 (VEGF)-A 的分级细胞外分布如何协调和平衡尖端和茎细胞的行为。最近的数据现在提供了对尖端细胞数量调节的深入了解，说明了 δ 样 (Dll)4-Notch 信号传导如何发挥作用来限制 VEGF-A 诱导的探索性尖端细胞行为。这些数据也为为什么并非所有受 VEGF-A 刺激的内皮细胞都转变为尖端细胞的问题提供了第一个答案。在这里，我们回顾这个新模型，并讨论 VEGF-A 和 Dll4/Notch 信号如何在细胞水平上动态相互作用以控制血管模式。
Tubular sprouting in angiogenesis relies on division of labour between endothelial tip cells, leading and guiding the sprout, and their neighboring stalk cells, which divide and form the vascular lumen. We previously learned how the graded extracellular distribution of heparin-binding vascular endothelial growth factor (VEGF)-A orchestrates and balances tip and stalk cell behavior. Recent data now provided insight into the regulation of tip cell numbers, illustrating how delta-like (Dll)4-Notch signalling functions to limit the explorative tip cell behavior induced by VEGF-A. These data also provided a first answer to the question why not all endothelial cells stimulated by VEGF-A turn into tip cells. Here we review this new model and discuss how VEGF-A and Dll4/Notch signalling may interact dynamically at the cellular level to control vascular patterning.