A new ozone-based method for virus inactivation: preliminary study
A new ozone-based method for virus inactivation: preliminary study
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DOI：
10.1088/0031-9155/42/11/002
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发表时间：
1997-11-01
影响因子：
3.5
通讯作者：
Sattar, SA
中科院分区：
文献类型：
--
作者：
Kekez, MM;Sattar, SA
本文报道的雾化技术可用于在短时间内用臭氧在大量体液（如血浆、部分血液或全血）中灭活病毒。大肠杆菌噬菌体MS2被用作模型，因为它是安全的，易于处理，比HIV等病毒更耐化学消毒。理论曲线和实验点，描述臭氧灭活MS 2，形成一个半S形的全等数据。MS2的存活率降低了>7log（10），并指出了使杀死病毒所需的臭氧浓度最小化的可能性。根据博尔顿等人的实验结果，分析被扩展到解释臭氧与薄膜状病毒悬浮液的相互作用。我们再次发现了半S形的全等数据。即描述甲型流感病毒（WSN株）和水泡性口炎病毒的臭氧灭活与时间的关系。对于雾化方法，液滴与臭氧的暴露时间为几秒，而对于薄膜方法，暴露时间以小时计。
The nebulization technique reported here could be used to inactivate viruses with ozone in large volumes of body fluids, such as plasma, partial blood and perhaps whole blood in a short time. Coliphage MS2 was used as a model because it is safe, easy to handle and more resistant to chemical disinfections than viruses such as HIV. The theoretical curves and experimental points, describing ozone inactivation of MS2, form a semi-sigmoid of congruent data. There was a >7log(10) reduction in MS2 viability and the possibilities of minimizing the ozone concentration required to kill viruses are indicated.The analysis was expanded to account for the interaction of ozone with a virus suspension in the shape of a thin film from the experimental findings of Bolton ei al. We again find a semi-sigmoid of congruent data for their case, i.e. describing ozone inactivation of the influenza A virus (WSN strain) and the vesicular stomatitis Virus versus time. For the method of nebulization, the exposure time of droplets with ozone is a few seconds, whereas for the thin film method the exposure time is measured in hours.