Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression.
Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression.
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Ets-1启动子相关非编码RNA调节NONO/ERG/Ets-1轴驱动胃癌进展
DOI：
10.1038/s41388-018-0302-4
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发表时间：
2018-08
期刊：
影响因子：
8
通讯作者：
Tong Q
中科院分区：
文献类型：
--
作者：
Li D;Chen Y;Mei H;Jiao W;Song H;Ye L;Fang E;Wang X;Yang F;Huang K;Zheng L;Tong Q
Emerging studies have indicated the essential functions of long noncoding RNAs (lncRNAs) during cancer progression. However, whether lncRNAs contribute to the upregulation of v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1), an established oncogenic protein facilitating tumor invasion and metastasis, in gastric cancer remains elusive. Herein, we identifiedEts-1promoter-associated noncoding RNA (pancEts-1) as a novel lncRNA associated with the gastric cancer progression via mining of publicly available datasets and rapid amplification of cDNA ends. RNA pull-down, RNA immunoprecipitation, in vitro binding, and RNA electrophoretic mobility shift assays indicated the binding ofpancEts-1to non-POU domain containing octamer binding (NONO) protein. Mechanistically,pancEts-1facilitated the physical interaction between NONO and Ets related gene (ERG), resulting in increased ERG transactivation and transcription ofEts-1associated with gastric cancer progression. In addition,pancEts-1facilitated the growth and aggressiveness of gastric cancer cells via interacting with NONO. In gastric cancer tissues,pancEts-1,NONO, andERGwere upregulated and significantly correlated withEts-1levels. High levels ofpancEts-1,NONO,ERG, orEts-1were respectively associated with poor survival of gastric cancer patients, whereas simultaneous expression of all of them (HR = 3.012,P= 0.105) was not an independent prognostic factor for predicting clinical outcome. Overall, these results demonstrate that lncRNApancEts-1exhibits oncogenic properties that drive the progression of gastric cancer via regulating the NONO/ERG/Ets-1 axis.
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